Plasmodium use digestive vacuoles (DV) to digest hemoglobin and heme from red blood cells into fuel sources for their life cycle. The DV is the site where host proteins are degraded by the parasite and then the peptide pieces are exported into the Plasmodium c
Plasmodium use digestive vacuoles (DV) to digest hemoglobin and heme from red blood cells into fuel sources for their life cycle. The DV is the site where host proteins are degraded by the
The cytosolic pH of Plasmodium is 7.1. Suppose PfCRT is a secondary active symporter using protons to drive VF-6-2 efflux from the digestive vacuole, DV. Suppose the membrane potential across the DV membrane is 50mV, inside positive. VF-6-2 has a 3nM concentration inside the DV and a 56nM concentration in the cytosol. What pH must the P-type ATPase establish inside of a digestive vacuole in order to allow PfCRT to spontaneously transport 1 VF-6-2 out of the DV with 1 H+ at 37°C?
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