A peptide has the sequence Glu–His–Trp–Ser–Gly–Leu–Arg–Pro–Gly The p?a values for the peptide’s side chains, terminal amino groups, and carboxyl groups are provided in the table.Amino acidAmino pKaCarboxyl pKaSide‑chain pKaglutamate9.609.602.342.344.254.25histidine9.179.171.821.826.006.00tryptophan9.399.392.382.38 serine9.159.152.212.21 glycine9.609.602.342.34 leucine9.609.602.362.36 arginine9.049.042.172.1712.4812.48proline10.9610.961.991.99 Calculate the net charge of the molecule at pH 11 and estimate the isoelectric point (pI)(pI) for this peptide.

Answered: peptide has the sequence

7th Edition

ISBN:9780618562763

Author:Steven S. Zumdahl

Publisher:Steven S. Zumdahl

Chapter21: Biochemistry

Section: Chapter Questions

Problem 6A

Related questions

Question

A peptide has the sequence

Glu–His–Trp–Ser–Gly–Leu–Arg–Pro–Gly

The p?a values for the peptide’s side chains, terminal amino groups, and carboxyl groups are provided in the table.

Amino acid	Amino pK_a	Carboxyl pK_a	Side‑chain pK_a
glutamate	9.609.60	2.342.34	4.254.25
histidine	9.179.17	1.821.82	6.006.00
tryptophan	9.399.39	2.382.38
serine	9.159.15	2.212.21
glycine	9.609.60	2.342.34
leucine	9.609.60	2.362.36
arginine	9.049.04	2.172.17	12.4812.48
proline	10.9610.96	1.991.99