Penicillin makes a covalent bond at the transpeptidase active site (which bond is it?) Why is it not hydrolyzed by water?

Chemistry for Today: General, Organic, and Biochemistry
9th Edition
ISBN:9781305960060
Author:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Publisher:Spencer L. Seager, Michael R. Slabaugh, Maren S. Hansen
Chapter19: Proteins
Section: Chapter Questions
Problem 19.50E
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Penicillin makes a covalent bond at the transpeptidase active site (which bond is it?) Why is it not hydrolyzed by water?

Codein is a prodrug for morphine (methyl ether derivative). What is the mechanism of prodrug activation ?

Sulfonamide is an isostere for which functional groups we've encountered? 

 

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