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Part II (2) Binding Probability, Disassociation Constant, and Binding Energy Suppose a drug has a disassociation constant K = InM for its target protein but also a disassociation constant. KOT=1uM for its off-target protein (i.e., the side effect). Answer the following questions assuming the temperature. is held at the room temperature (T=300K). If the drug concentration is c= 2nM, what is the percentage of the target protein bound by the drug? What about the off-target protein? (b) What is the binding energy difference between the target site and the off-target site? (c) If a protein has two binding sites with drug A targeting one site and another drug B targeting the other site as shown in FIG. 2 below. If drug A and B have disassociation constants K and K, respectively. What is the disassociation constant K for a composite drug C that links A and B (C-A-B)? We will assume that C either binds to the protein completely, as shown in FIG. 2, or not at all (i.e., no partial binding). Ding a=● Drug b= Drug C= 5 protein

Part II (2) Binding Probability, Disassociation Constant, and Binding Energy Suppose a drug has a disassociation constant K = InM for its target protein but also a disassociation constant. KOT=1uM for its off-target protein (i.e., the side effect). Answer the following questions assuming the temperature. is held at the room temperature (T=300K). If the drug concentration is c= 2nM, what is the percentage of the target protein bound by the drug? What about the off-target protein? (b) What is the binding energy difference between the target site and the off-target site? (c) If a protein has two binding sites with drug A targeting one site and another drug B targeting the other site as shown in FIG. 2 below. If drug A and B have disassociation constants K and K, respectively. What is the disassociation constant K for a composite drug C that links A and B (C-A-B)? We will assume that C either binds to the protein completely, as shown in FIG. 2, or not at all (i.e., no partial binding). Ding a=● Drug b= Drug C= 5 protein

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Part II (2) Binding Probability, Disassociation Constant, and Binding Energy Suppose a drug has a disassociation constant K KT = 1µM for its off-target protein (i.e., the side effect). Answer the following questions assuming the temperature is held at the room temperature (T = 300K). = InM for its target protein but also a disassociation constant (a) What about the off-target protein? If the drug concentration is c= 2nM, what is the percentage of the target protein bound by the drug? (b) What is the binding energy difference between the target. site and the off-target site? If a protein has two binding sites with drug A targeting one site and another drug B targeting the other (c) sitc as shown in FIG. 2 below. If drug A and B have disassociation constants Kg and K, respectively. What is the disassociation constant K for a composite drug C that links A and B (C=A-B)? We will assume that C either binds to the protein completely, as shown in FIG. 2, or not at all (i.e., no partial binding). Dag a =0 Drug b= Drug c= proteln Ea FIG. 2: Composite Drug C
Transcribed Image Text:Part II (2) Binding Probability, Disassociation Constant, and Binding Energy Suppose a drug has a disassociation constant K KT = 1µM for its off-target protein (i.e., the side effect). Answer the following questions assuming the temperature is held at the room temperature (T = 300K). = InM for its target protein but also a disassociation constant (a) What about the off-target protein? If the drug concentration is c= 2nM, what is the percentage of the target protein bound by the drug? (b) What is the binding energy difference between the target. site and the off-target site? If a protein has two binding sites with drug A targeting one site and another drug B targeting the other (c) sitc as shown in FIG. 2 below. If drug A and B have disassociation constants Kg and K, respectively. What is the disassociation constant K for a composite drug C that links A and B (C=A-B)? We will assume that C either binds to the protein completely, as shown in FIG. 2, or not at all (i.e., no partial binding). Dag a =0 Drug b= Drug c= proteln Ea FIG. 2: Composite Drug C
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