Part II (2) Binding Probability, Disassociation Constant, and Binding Energy Suppose a drug has a disassociation constant K = InM for its target protein but also a disassociation constant. KOT=1uM for its off-target protein (i.e., the side effect). Answer the following questions assuming the temperature. is held at the room temperature (T=300K). If the drug concentration is c= 2nM, what is the percentage of the target protein bound by the drug? What about the off-target protein? (b) What is the binding energy difference between the target site and the off-target site? (c) If a protein has two binding sites with drug A targeting one site and another drug B targeting the other site as shown in FIG. 2 below. If drug A and B have disassociation constants K and K, respectively. What is the disassociation constant K for a composite drug C that links A and B (C-A-B)? We will assume that C either binds to the protein completely, as shown in FIG. 2, or not at all (i.e., no partial binding). Ding a=● Drug b= Drug C= 5 protein

Part II (2) Binding Probability, Disassociation Constant, and Binding Energy Suppose a drug has a disassociation constant K = InM for its target protein but also a disassociation constant. KOT=1uM for its off-target protein (i.e., the side effect). Answer the following questions assuming the temperature. is held at the room temperature (T=300K). If the drug concentration is c= 2nM, what is the percentage of the target protein bound by the drug? What about the off-target protein? (b) What is the binding energy difference between the target site and the off-target site? (c) If a protein has two binding sites with drug A targeting one site and another drug B targeting the other site as shown in FIG. 2 below. If drug A and B have disassociation constants K and K, respectively. What is the disassociation constant K for a composite drug C that links A and B (C-A-B)? We will assume that C either binds to the protein completely, as shown in FIG. 2, or not at all (i.e., no partial binding). Ding a=● Drug b= Drug C= 5 protein

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Question

Part II (2) Binding Probability, Disassociation Constant, and Binding Energy
Suppose a drug has a disassociation constant K
KT = 1µM for its off-target protein (i.e., the side effect). Answer the following questions assuming the temperature
is held at the room temperature (T = 300K).
= InM for its target protein but also a disassociation constant
(a)
What about the off-target protein?
If the drug concentration is c= 2nM, what is the percentage of the target protein bound by the drug?
(b)
What is the binding energy difference between the target. site and the off-target site?
If a protein has two binding sites with drug A targeting one site and another drug B targeting the other
(c)
sitc as shown in FIG. 2 below. If drug A and B have disassociation constants Kg and K, respectively. What is the
disassociation constant K for a composite drug C that links A and B (C=A-B)? We will assume that C either binds
to the protein completely, as shown in FIG. 2, or not at all (i.e., no partial binding).
Dag a =0
Drug b=
Drug c=
proteln
Ea
FIG. 2: Composite Drug C

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