3. (Part A) The intermediates of a pathway are shown in the following scheme. Using curvedarrows, show the mechanism of each step labeled with a blue letter. Draw out the structures ofall coenzymes, so that you can effectively show all arrow pushing. You may abbreviate thecoenzymes by putting R groups on the molecule, but do draw out the parts of the structure thatare involved in the arrow pushing.Please note that some of the transformations will require you to show multiple structures toshow all of the arrow pushing (particularly some of the coenzyme-mediated steps). You do notneed to show specific amino acid residues that perform the catalysis. You can abbreviate acidicamino acid residues "Enz-B-H" and basic residues "B-Enz".HOOOHONH₂OHATP ADP(A)H₂O3POH₂O(D)O NH₂OHO.OOHNADPH(B)NADP+OHILI I IgrOHHOOHO OH NH₂O NH₂H₂OOH(E)(C)OHOH

The metabolic pathway in question involves the conversion of the amino acid aspartate to chelidamic…

Answered: (Part A) The intermediates of a pathway…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Identify different types of organic reaction mechanims in the followingmetabolic pathways.1. Catabolism of triacylglycerols- beta-oxidation pathway2. Biosynthesis of fatty acids from Acetyl CoA3. Glycolysis (from glucose to two molecules of pyruvate)
There are eight chemical reactions that occur in the citric acid cycle process. The reactions of the citric acid cycle are shown in the figure below. Several classes of organic reactions like these classes include esterification, decarboxylation, hydration reactions, dehydration of alcohols, oxidation of alcohols, oxidation of aldehydes, reduction of aldehydes, and reduction of ketones. Find at least one of these reaction classes in the citric acid cycle. List the reaction number and the reaction. Write a sentence or two on how you were able to make the classification.
Give the two reasons why anabolic reactions in metabolism are not exactly the reverse of catabolic pathway.
The mechanism of chymotrypsin is used as a model for studying enzyme reaction mechanisms. Answer the following questions related to chymotrypsin: 1. List the 3 amino acids in the catalytic triad of chymotrypsin. 2. List the types of catalytic mechanisms (from the 3 main types of catalytic mechanisms) displayed in the mechanism of chymotrypsin.
The enzyme pyruvate carboxylase is discovered in a bacterium that was thought not to contain it; in this case study, you’ll see how researchers study and characterize the enzyme, and, ultimately, show how it fits into a metabolic pathway. Following purification of the PYC enzyme by avidin-Sepharose affinity chromatography, the investigators carried out several experiments to characterize the enzyme. First, they ran samples of the enzyme on denaturing and non-denaturing gels; the results are shown in the figure to the right. In addition, they ran the protein through a calibrated gel filtration column, the results of which indicated that the PYC enzyme had a molecular weight of 540 kiloDaltons. In the figure, the rightmost column are where molecular weight standards of various sizes would occur if they’d been on the gels. The catalytic properties of the PYC enzyme were assessed following purification. The activity of the enzyme was assayed in the presence of ATP, pyruvate, bicarbonate…
Describe how coenzyme A is important in the thiolase-catalyzed reaction.
Write balanced equations for the three known reactions that transfer an amino group to a substrate by condensation with aspartate to give an intermediate that then undergoes a,B-elimination to give the product plus fumarate.
What reaction does beta-glucanase catalyses. Write in detail with examples.
Explain why, glucose-6-phosphate will prefer to go via the pentose phosphate route. What additional chemical is created by this route, and what role does it play in anabolic pathways?
Use drawings to explain how an enzyme (such as hexokinase, mentioned in the text) can distinguish its normal substrate (here d-glucose) from the optical isomer l-glucose, which is not a substrate. (hint: remembering that a carbon atom forms four single bonds that are tetrahedrally arranged and that the optical isomers are mirror images of each other around such a bond, draw the substrate as a simple tetrahedron with four different corners and then draw its mirror image. using this drawing, indicate why only one optical isomer might bind to a schematic active site of an enzyme.)
Part A Using abbreviations (not structures), write the reaction of coenzyme A that gives off energy (-AG). Match the items in the left column to the appropriate blanks in the equation on the right. CoA+ acetate acetyl acetyl CoA. COA acetyl Previous Answers Request Answer Submit Reset Help
We have encountered reactions similar to the oxidation, hydration, and oxidation reactions of fatty acid degradation earlier in our study of biochemistry. What other pathway employs this set of reactions?

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