Part [2] Addition of the nucleophile and loss of the leaving group н. :0: :ö: :ö: н. :0: R' N: R: N: R. nucleophilic attack H-N loss of the leaving group н Н н R' R' R'NH2 amide 3 Nucleophilic attack of the amine on the activated carboxy group forms a tetrahedral intermediate. 4 - 5 Proton transfer and elimination of dicyclohexylurea as the leaving group form the amide. The reaction of an acid and an amine with DCC is often used in the laboratory to form the amide bond in peptides, as is Page 903 discussed in Chapter 26 (2 Problem 22.19 What product is formed when acetic acid is treated with each reagent: (a) CH,NH,; (b) CH-NH,, then
Part [2] Addition of the nucleophile and loss of the leaving group н. :0: :ö: :ö: н. :0: R' N: R: N: R. nucleophilic attack H-N loss of the leaving group н Н н R' R' R'NH2 amide 3 Nucleophilic attack of the amine on the activated carboxy group forms a tetrahedral intermediate. 4 - 5 Proton transfer and elimination of dicyclohexylurea as the leaving group form the amide. The reaction of an acid and an amine with DCC is often used in the laboratory to form the amide bond in peptides, as is Page 903 discussed in Chapter 26 (2 Problem 22.19 What product is formed when acetic acid is treated with each reagent: (a) CH,NH,; (b) CH-NH,, then
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Im sorry but i dont understand the following:
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I just asked what where did the hydrogen in green go. It is a worked out practice problem. They already give the answer and I dont understand a step.
![Part [2] Addition of the nucleophile and loss of the leaving group
н.
:0:
:ö:
:ö:
н.
:0:
R'
N:
R:
N:
R.
nucleophilic
attack
H-N
loss of the
leaving group
н
Н
н
R'
R'
R'NH2
amide
3 Nucleophilic attack of the amine on the activated carboxy group forms a tetrahedral intermediate.
4 - 5 Proton transfer and elimination of dicyclohexylurea as the leaving group form the amide.
The reaction of an acid and an amine with DCC is often used in the laboratory to form the amide bond in peptides, as is Page 903
discussed in Chapter 26 (2
Problem 22.19
What product is formed when acetic acid is treated with each reagent: (a) CH,NH,; (b) CH-NH,, then](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F82a08560-2714-41d6-a009-aad50ffff1b9%2F971462ff-56a4-45e5-86fd-a2fac8e63ada%2F2wl7nw.png&w=3840&q=75)
Transcribed Image Text:Part [2] Addition of the nucleophile and loss of the leaving group
н.
:0:
:ö:
:ö:
н.
:0:
R'
N:
R:
N:
R.
nucleophilic
attack
H-N
loss of the
leaving group
н
Н
н
R'
R'
R'NH2
amide
3 Nucleophilic attack of the amine on the activated carboxy group forms a tetrahedral intermediate.
4 - 5 Proton transfer and elimination of dicyclohexylurea as the leaving group form the amide.
The reaction of an acid and an amine with DCC is often used in the laboratory to form the amide bond in peptides, as is Page 903
discussed in Chapter 26 (2
Problem 22.19
What product is formed when acetic acid is treated with each reagent: (a) CH,NH,; (b) CH-NH,, then
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