P18.19 A technique for radioactively labeling proteins is electrophilic radioiodination inwhich an aromatic substitution of 131I onto a tyrosine residue is performed as follows:R131| +131|OHOHUsing the activity of 131I, one can measure protein lifetimes in a variety of biologicalprocesses. 131I undergoes beta decay with a half-life of 8.02 days. Initially, a proteinlabeled with 1311I has a specific activity of 1.0 µuCi, which corresponds to 37,000 decayevents every second. The protein is suspended in aqueous solution and exposed tooxygen for 5 days. After isolating the protein from solution, the protein sample is foundto have a specific activity of 1.0 µCi. Is oxygen reacting with the tyrosine residues of theprotein, resulting in the loss of 131I?

I131 is a radioactive substance with half-life, t1/2 = 8.02 days

P18.19 A technique for radioactively labeling proteins is electrophilic radioiodination in which an aromatic substitution of 131I onto a tyrosine residue is performed as follows: R R 131| + 131| OH OH Using the activity of 13I, one can measure protein lifetimes in a variety of biological processes. 131I undergoes beta decay with a half-life of 8.02 days. Initially, a protein labeled with 131I has a specific activity of 1.0 µCi, which corresponds to 37,000 decay events every second. The protein is suspended in aqueous solution and exposed to oxygen for 5 days. After isolating the protein from solution, the protein sample is found to have a specific activity of 1.0 µCi. Is oxygen reacting with the tyrosine residues of the protein, resulting in the loss of 1311?

P18.19 A technique for radioactively labeling proteins is electrophilic radioiodination in which an aromatic substitution of 131I onto a tyrosine residue is performed as follows: R R 131| + 131| OH OH Using the activity of 13I, one can measure protein lifetimes in a variety of biological processes. 131I undergoes beta decay with a half-life of 8.02 days. Initially, a protein labeled with 131I has a specific activity of 1.0 µCi, which corresponds to 37,000 decay events every second. The protein is suspended in aqueous solution and exposed to oxygen for 5 days. After isolating the protein from solution, the protein sample is found to have a specific activity of 1.0 µCi. Is oxygen reacting with the tyrosine residues of the protein, resulting in the loss of 1311?

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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