Order the following Acid Derivatives from most reactive to least reactive. "NH2 C

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Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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**Reactivity of Acid Derivatives**

**Objective:** Order the following acid derivatives from most reactive to least reactive.

**Compounds:**
- **A**: Benzoic acid
- **B**: Benzoic anhydride
- **C**: Benzoic ester
- **D**: Benzoyl chloride
- **E**: Benzamide

### Explanation:
The reactivity of acid derivatives typically follows the order: acyl chlorides > anhydrides > esters > amides.

1. **Benzoyl chloride (D)**: The most reactive due to the presence of a good leaving group (chloride ion).
2. **Benzoic anhydride (B)**: Next in reactivity as it can readily lose an acyl group.
3. **Benzoic ester (C)**: Less reactive than anhydrides but more reactive than amides.
4. **Benzamide (E)**: The least reactive as amides have strong resonance stabilization.
5. **Benzoic acid (A)**: Not typically classified under the 'reactive' derivatives of carboxylic acids for nucleophilic acyl substitution without activation.

This information helps in understanding the behavior of different acid derivatives in chemical reactions.
Transcribed Image Text:**Reactivity of Acid Derivatives** **Objective:** Order the following acid derivatives from most reactive to least reactive. **Compounds:** - **A**: Benzoic acid - **B**: Benzoic anhydride - **C**: Benzoic ester - **D**: Benzoyl chloride - **E**: Benzamide ### Explanation: The reactivity of acid derivatives typically follows the order: acyl chlorides > anhydrides > esters > amides. 1. **Benzoyl chloride (D)**: The most reactive due to the presence of a good leaving group (chloride ion). 2. **Benzoic anhydride (B)**: Next in reactivity as it can readily lose an acyl group. 3. **Benzoic ester (C)**: Less reactive than anhydrides but more reactive than amides. 4. **Benzamide (E)**: The least reactive as amides have strong resonance stabilization. 5. **Benzoic acid (A)**: Not typically classified under the 'reactive' derivatives of carboxylic acids for nucleophilic acyl substitution without activation. This information helps in understanding the behavior of different acid derivatives in chemical reactions.
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