O What is the net gain in ATP for ß-oxidation of palmitic acid (a sixteen-carbon fatty acid)? ANSWER: 107 ATP EXPLANATION: , palmitic acid is activated to produce a 16-carbon acyl-CoA. The activation step consumes one ATP. -carbon fatty acyl-CoA will undergo seven ß-oxidation _ls. Each of the first six spirals of ß-oxidation produces acetyl-CoA, one NADH, and one FADH₂. The final of the spiral produces two acetyl-CoA, one NADH, one FADH₂. The acetyl-CoA are processed through itric acid cycle, producing ATP and more reduced zymes. The NADH, and FADH₂ formed in ß- ation, and the NADH, and FADH₂ formed in the citric cycle undergo oxidative phosphorylation. Because ATP was consumed in the activation reaction, it is acted when calculating the net gain of ATP. ß- ation of a sixteen-carbon fatty acid, on average, results met gain of 107 ATP. fatty acyl-CoA with 16 carbons CHÍCH CH-CH-CH-CH-CH-CH-CHCHCHCHCHCHCHC–CaA fatty acyl-CoA with 4 carbons O For more details: See chapter 15 part 11 video or fatty acyl-CoA with 14 carbons CHCHÍCH CHÍCH CHÍCH CHCHCHCH,CH,CHC–CoA fatty acyl-CoA with 10 carbons CHÍCH CHCHCH CHÍCH-CH-CHC–CHA fatty acyl-CoA with 8 carbons 9 CHCHCH;CH CHCHCH2–Cas acetyl-CoA fatty acyl-CoA with 12 carbons CH;CH_CH,CH,CH,CH,CH,CH,CH,CH,CH;C —CeA fatty acyl-CoA with 6 carbons CH,CHỊCH,CH,CHC–CoA CH₂CH₂CH₂C-CoA) -‒‒‒‒‒ Total: 8 acetyl-CoA Citric Acid Cycle Subtract one ATP that was used in the activation reaction 8 ATP 22.5 ATP 0 77.5 ATP -1 ATP acetyl-CoA FADH₂ acetyl-CoA FADH₂ + NADH acetyl-CoA+FADH₂ NADH acetyl-CoA+FADH₂ + NADH NADH acetyl-CoA FADH₂ + NADH acetyl-CoA+ FADH₂ NADH acetyl-CoA+FADH₂ Oxidative Phosphorylation 1.5 ATP 1 FADH₂ 2.5 ATP 1 NADH NADH 8 FADH₂ + 24 NADH Totals: 15 FADH₂ 31 NADH
O What is the net gain in ATP for ß-oxidation of palmitic acid (a sixteen-carbon fatty acid)? ANSWER: 107 ATP EXPLANATION: , palmitic acid is activated to produce a 16-carbon acyl-CoA. The activation step consumes one ATP. -carbon fatty acyl-CoA will undergo seven ß-oxidation _ls. Each of the first six spirals of ß-oxidation produces acetyl-CoA, one NADH, and one FADH₂. The final of the spiral produces two acetyl-CoA, one NADH, one FADH₂. The acetyl-CoA are processed through itric acid cycle, producing ATP and more reduced zymes. The NADH, and FADH₂ formed in ß- ation, and the NADH, and FADH₂ formed in the citric cycle undergo oxidative phosphorylation. Because ATP was consumed in the activation reaction, it is acted when calculating the net gain of ATP. ß- ation of a sixteen-carbon fatty acid, on average, results met gain of 107 ATP. fatty acyl-CoA with 16 carbons CHÍCH CH-CH-CH-CH-CH-CH-CHCHCHCHCHCHCHC–CaA fatty acyl-CoA with 4 carbons O For more details: See chapter 15 part 11 video or fatty acyl-CoA with 14 carbons CHCHÍCH CHÍCH CHÍCH CHCHCHCH,CH,CHC–CoA fatty acyl-CoA with 10 carbons CHÍCH CHCHCH CHÍCH-CH-CHC–CHA fatty acyl-CoA with 8 carbons 9 CHCHCH;CH CHCHCH2–Cas acetyl-CoA fatty acyl-CoA with 12 carbons CH;CH_CH,CH,CH,CH,CH,CH,CH,CH,CH;C —CeA fatty acyl-CoA with 6 carbons CH,CHỊCH,CH,CHC–CoA CH₂CH₂CH₂C-CoA) -‒‒‒‒‒ Total: 8 acetyl-CoA Citric Acid Cycle Subtract one ATP that was used in the activation reaction 8 ATP 22.5 ATP 0 77.5 ATP -1 ATP acetyl-CoA FADH₂ acetyl-CoA FADH₂ + NADH acetyl-CoA+FADH₂ NADH acetyl-CoA+FADH₂ + NADH NADH acetyl-CoA FADH₂ + NADH acetyl-CoA+ FADH₂ NADH acetyl-CoA+FADH₂ Oxidative Phosphorylation 1.5 ATP 1 FADH₂ 2.5 ATP 1 NADH NADH 8 FADH₂ + 24 NADH Totals: 15 FADH₂ 31 NADH
Human Anatomy & Physiology (11th Edition)
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Question
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Answer should be 107 ATP. Can u help me to explain to me, please? I stuggled.
Transcribed Image Text:15.22) What is the net gain in ATP for ß-oxidation of
palmitic acid (a sixteen-carbon fatty acid)?
ANSWER: 107 ATP
EXPLANATION:
First, palmitic acid is activated to produce a 16-carbon
fatty acyl-CoA. The activation step consumes one ATP.
A 16-carbon fatty acyl-CoA will undergo seven ß-oxidation
spirals. Each of the first six spirals of ß-oxidation produces
one acetyl-CoA, one NADH, and one FADH₂. The final
cycle of the spiral produces two acetyl-CoA, one NADH,
and one FADH₂. The acetyl-CoA are processed through
the citric acid cycle, producing ATP and more reduced
coenzymes. The NADH, and FADH₂ formed in ß-
oxidation, and the NADH, and FADH₂ formed in the citric
acid cycle undergo oxidative phosphorylation. Because
one ATP was consumed in the activation reaction, it is
subtracted when calculating the net gain of ATP. B-
oxidation of a sixteen-carbon fatty acid, on average, results
in a net gain of 107 ATP.
fatty acyl-CoA
with 16 carbons
| CHỊCH CHỊCH,CH,CH_CH,CHCH,CH,CH,CH,CH,CH,CH,C –CoA
fatty acyl-CoA
with 4 carbons
fatty acyl-CoA
with 14 carbons
| CH,CH;CH;CH;CH,CH;CH,CH,CH;CH;CH,CHỊCH,C—COA
fatty acyl-CoA
with 10 carbons
CH₂CH₂CH₂CH₂CH₂CH₂CH₂CH₂CH₂C
For more details: See chapter 15 part 11 video or
fatty acyl-CoA
with 12 carbons
CHCHCH,CH,CHCHCH CHÍCH CHÍCH,C–Cos
fatty acyl-CoA
with 8 carbons
CH,CHỊCH;CH,CH_CH,CH,—CoA
fatty acyl-CoA
with 6 carbons
| CH,CH;CH;CH;CH,C…CA
acetyl-CoA
CH₂CH₂CH₂C-COA
-‒‒‒‒ Total: 8 acetyl-CoA
Citric
Acid
Cycle
Subtract one ATP that was used
in the activation reaction
8 ATP
22.5 ATP
77.5 ATP
-1 ATP
acetyl-CoA
23
acetyl-CoA FADH₂ + NADH
acetyl-CoA
acetyl-CoA
acetyl-CoA FADH₂ NADH
acetyl-CoA
acetyl-CoA
FADH₂ + NADH
1.5 ATP
1 FADH₂
FADH₂ + NADH
2.5 ATP
1 NADH
FADH₂ NADH
FADH₂ + NADH
Totals:
Oxidative Phosphorylation 15 FADH₂ 31 NADH
FADH₂ + NADH
8 FADH₂ + 24 NADH
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