Nifedipine (Procardia and Adalat) belongs to a class of drugs called calcium channel blockers and is effective in the treatment of various types of angina, including that in- duced by exercise. Show how nifedipine can be synthesized from 2-nitrobenzaldehyde, methyl acetoacetate, and ammonia. (Hint: Review the chemistry of your answers to Problems 19.43 and 19.54 and then combine that chemistry to solve this problem.) NO COOME MEOOC, acid + 2 `NO2 OMe +NH3 СНО H Nifedipine

Nifedipine (Procardia and Adalat) belongs to a class of drugs called calcium channel blockers and is effective in the treatment of various types of angina, including that in- duced by exercise. Show how nifedipine can be synthesized from 2-nitrobenzaldehyde, methyl acetoacetate, and ammonia. (Hint: Review the chemistry of your answers to Problems 19.43 and 19.54 and then combine that chemistry to solve this problem.) NO COOME MEOOC, acid + 2 `NO2 OMe +NH3 СНО H Nifedipine

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Similar questions

What change can be made to allow for a faster rate of reaction if poor solubility of KOH in ethanol slowed the rate and led to slow deprotonation of dibenzyl ketone?
What is a reasonable synthetic pathway on how benzoyl chloride can be synthesized to form N-(2-phenylethyl) aniline?
If possible would you be able to solve and explain these questions?
Which of the following acid derivatives can be hydrolyzed in water spontaneously without acid or base catalysis? Benzamide Methyl benzoate Benzonitrile Benzoyl chloride
The dissociation of triethylphosphine is faster than the phosphorous trifluoride. Explain the phenomena.
nitriles can be obtained by the reaction of sodium cyanide with an alkyl halide. starting from hexyl bromide, hexyl cyanide is obtained. If this reaction is carried out in methanol, the reaction is completed after 20 hours of heating, whereas only 20 minutes are required if the reaction is carried out in dimethyl sulfoxide propose an explanation for the effect of the solvent on the observed reactivity, why could the time taken be longer
Explain oxidative and reductive Ozonolysis. Give the sequence of the relative reactivities of carboxylic acid derivatives. Explain why acyl chloride can be converted into ester but ester cannot be converted into acyl chloride? Write the product when ester of propionic acid, propionyl chloride and propanal reacts with excess of methyl magnesium bromide .
A common illicit synthesis of methamphetamine involves an interesting variation of the Birch reduction. A solution of ephedrine in alcohol is added to liquid ammonia, followed by several pieces of lithium metal. The Birch reduction usually reduces the aromatic ring, but in this case it eliminates the hydroxy group of ephedrine to give methamphetamine. Propose a mechanism, similar to that for the Birch reduction, to explain this unusual course of the reaction.
Define the carbon bond-forming reactions of enolates with carbonyl electrophiles ?
explain why sulfonate esters are such good leaving groups, in terms of structure and bonding
write structural formulas for the products that form when propanal reacts with phenylhydrazine. draw a step by step mech
Define what is reduction reaction, reducing agents, weak and strong reducing agents sodium borohydride reduction with benzophenone and sodium borohyride to get benzophenone