### Activity: Organic Synthesis PathwayNatural products that contain the N-1,1-dimethyl-2-propenyl group often exhibit antifungal or antitumor activity. The synthesis of one such compound begins with the two steps shown here.**Reaction Scheme:**1. Starting Material: Compound 1 (Indole structure)2. Intermediate: Compound 2 (product of the reaction with acetoxydimethylpropyne and base)3. Final Product: Compound 3 (possessing the N-1,1-dimethyl-2-propenyl group)**Reaction Steps:**- **Step 1:** - Reagents: Acetoxydimethylpropyne (shown with OAc leaving group), CuCl (catalyst), and i-Pr2NEt (base). - Transformation: Compound 1 reacts to form compound 2 via an intermediate step.- **Step 2:** - Compound 2 is further processed to yield Compound 3.**Structural Diagrams:**- **Compound 1:** The structure is an indole with a secondary amine at the nitrogen position.- **Compound 2:** This structure is derived from the reaction but needs to be drawn specifically.- **Compound 3:** The final structure is an indole with an N-1,1-dimethyl-2-propenyl group attached to the nitrogen.**Questions:****a. Draw the structure of compound 2 and show a reasonable mechanism for its formation. CuCl is used as a catalyst (behaving similarly to an acid) and i-Pr2NEt is a base. The former can be ignored in your mechanism.**- For this task, students would need to: - Identify the structure of Compound 2 based on its precursor (indole) and the chemical reagents provided. - Show the steps in the mechanism, illustrating how the base i-Pr2NEt facilitates the reaction to form Compound 2.**b. Identify the reagents necessary for the conversion of 2 to 3.**- Here, students must determine which chemical reagents would be used to convert the intermediate Compound 2 to the final product Compound 3, highlighting the functional group transformation that takes place.**Graph/Diagram Descriptions:**- The reaction schematic shows linear progression from Compound 1 (starting material) to Compound 3 (final product), with an

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Natural products that contain the N-1,1-dimethyl-2-propenyl group often exhibit antifungal or antitumor activity. The synthesis of one such compound begins with the two steps shown here. OAc C13H15N CuCI, -Pr,NEt 2 a. Draw the structure of compound 2 and show a reasonable mechanism for its formation. CuCl is used as a catalyst (behaving similarly to an acid) and i-PR2NET is a base. The former can be ignored in your mechanism. b. Identify the reagents necessary for the conversion of 2 to 3.

Natural products that contain the N-1,1-dimethyl-2-propenyl group often exhibit antifungal or antitumor activity. The synthesis of one such compound begins with the two steps shown here. OAc C13H15N CuCI, -Pr,NEt 2 a. Draw the structure of compound 2 and show a reasonable mechanism for its formation. CuCl is used as a catalyst (behaving similarly to an acid) and i-PR2NET is a base. The former can be ignored in your mechanism. b. Identify the reagents necessary for the conversion of 2 to 3.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Sulfur Functional Groups

Many organic molecules contain sulfur functional groups and have their own importance in chemistry as well as biology. Some of the organic molecules which contain sulfur functional groups and the corresponding sulfur functionality is given below:

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### Activity: Organic Synthesis Pathway

Natural products that contain the N-1,1-dimethyl-2-propenyl group often exhibit antifungal or antitumor activity. The synthesis of one such compound begins with the two steps shown here.

**Reaction Scheme:**
1. Starting Material: Compound 1 (Indole structure)
2. Intermediate: Compound 2 (product of the reaction with acetoxydimethylpropyne and base)
3. Final Product: Compound 3 (possessing the N-1,1-dimethyl-2-propenyl group)

**Reaction Steps:**
- **Step 1:**
- Reagents: Acetoxydimethylpropyne (shown with OAc leaving group), CuCl (catalyst), and i-Pr2NEt (base).
- Transformation: Compound 1 reacts to form compound 2 via an intermediate step.
- **Step 2:**
- Compound 2 is further processed to yield Compound 3.

**Structural Diagrams:**
- **Compound 1:** The structure is an indole with a secondary amine at the nitrogen position.
- **Compound 2:** This structure is derived from the reaction but needs to be drawn specifically.
- **Compound 3:** The final structure is an indole with an N-1,1-dimethyl-2-propenyl group attached to the nitrogen.

**Questions:**

**a. Draw the structure of compound 2 and show a reasonable mechanism for its formation. CuCl is used as a catalyst (behaving similarly to an acid) and i-Pr2NEt is a base. The former can be ignored in your mechanism.**

- For this task, students would need to:
- Identify the structure of Compound 2 based on its precursor (indole) and the chemical reagents provided.
- Show the steps in the mechanism, illustrating how the base i-Pr2NEt facilitates the reaction to form Compound 2.

**b. Identify the reagents necessary for the conversion of 2 to 3.**

- Here, students must determine which chemical reagents would be used to convert the intermediate Compound 2 to the final product Compound 3, highlighting the functional group transformation that takes place.

**Graph/Diagram Descriptions:**
- The reaction schematic shows linear progression from Compound 1 (starting material) to Compound 3 (final product), with an

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