7. Glucose-6-phosphate dehydrogenase catalyzes the reaction shown below. Kinetic datafor the enzyme isolated from the thermophilic bacterium T. maritima are presented in thefollowing table.CH₂OPOHноCH₂OPOOH HHOHНOHGlucose-6-phosphateSubstrateNADP+NAD+NADP+Glucose-6-phosphateNADPH + H+glucose-6-phosphatedehydrogenaseH12.0НОHOH HΗOH6-Phosphoglucono-8-lactoneKM (mM) Vmax (Umg-¹)0.15 200.03206a. NADPH inhibits glucose-6-phosphate dehydrogenase. What kind of inhibitor isNADPH?b. How are the values of KM and Vmax likely to differ from those listed in the table ifNADPH is present?c. Does glucose-6-phosphate dehydrogenase prefer NAD+ or NADP+ as acofactor?

Glucose-6-phosphate dehydrogenase (G6PD) is found in the cells of many organisms. It plays an…

Answered: NADPH inhibits glucose-6-phosphate…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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NADPH inhibits glucose-6-phosphate dehydrogenase. What kind of inhibitor is NADPH?