NAD+ NADH + H* NAD* NADH + H* ܘ H CH3-CH2-OH - ADH » CH3-C=O - ALDH » CH3-C-OH Ethanol Acetaldehyde Acetate

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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Ethanol metabolism has been part of the human diet for centuries. Ethanol cannot be excreted and must be metabolized by the liver using the enzyme alcohol dehydrogenase in a two-step reaction: 

 

Excess consumption of ethanol leads to the accumulation of NADH. What effect would a high concentration of NADH have on metabolic pathways and consequently the body. Choose as least two pathways to describe the effect.

NAD+ NADH + H*
NAD*
NADH + H*
ܘ
H
CH3-CH2-OH - ADH » CH3-C=O - ALDH
» CH3-C-OH
Ethanol
Acetaldehyde
Acetate
Transcribed Image Text:NAD+ NADH + H* NAD* NADH + H* ܘ H CH3-CH2-OH - ADH » CH3-C=O - ALDH » CH3-C-OH Ethanol Acetaldehyde Acetate
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