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What can you infer regarding the function of Aquaporin 3? b. How will the drug treat constipation? Use the given image as a guide in answering the question

What can you infer regarding the function of Aquaporin 3? b. How will the drug treat constipation? Use the given image as a guide in answering the question

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Emodin (a laxative) is used to treat constipation. This drug inhibits Aquaporin 3 located in the cells lining the colon. a. What can you infer regarding the function of Aquaporin 3? b. How will the drug treat constipation? Use the given image as a guide in answering the question
ANOTHER EXAMPLE OF CHANNEL PROTEIN: AQUAPORINS Channel proteins specific for water molecules Found mainly in kidneys (nephrons) Primary filtrate pass thru tubules of nephrons until Aquaporin1 for reabsorption of 70% of water back to circulatory system then to Aquaporin2 for another reabsorption of 10% of water The amount of Aquaporin2 will depend on vasopressin, an antidiuretic hormone An increase in the number of Aquaporin2 will also increase the water resorption rate (usually in response to possible dehydration) Aquaglyceroporins -accommodates ammonia, urea, water, and glycerol
Transcribed Image Text:ANOTHER EXAMPLE OF CHANNEL PROTEIN: AQUAPORINS Channel proteins specific for water molecules Found mainly in kidneys (nephrons) Primary filtrate pass thru tubules of nephrons until Aquaporin1 for reabsorption of 70% of water back to circulatory system then to Aquaporin2 for another reabsorption of 10% of water The amount of Aquaporin2 will depend on vasopressin, an antidiuretic hormone An increase in the number of Aquaporin2 will also increase the water resorption rate (usually in response to possible dehydration) Aquaglyceroporins -accommodates ammonia, urea, water, and glycerol
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