Mendel’s experiments used plants that had traits which follow simple laws of dominance, segregation, and independent assortment. We have since learned that not all traits follow these simple laws. Give at least three examples of non-Mendelian inheritance patterns and explain how each differs from Mendel’s laws of inheritance.
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- Mendel’s experiments used plants that had traits which follow simple laws of dominance, segregation, and independent assortment. We have since learned that not all traits follow these simple laws. Give at least three examples of non-Mendelian inheritance patterns and explain how each differs from
Mendel’s laws of inheritance.
Gregor Johann Mendel was a scientist known as the Father and Founder of Genetics. Mendel performed many experiments on pea plants ( Pisum sativum) between 1856 and 1863. He researched test results and came up with many ideas. Thus, estate laws or Mendel's estate laws came into existence.
Mendel proposed three laws:
- Law of Dominance
- The Law of Segregation
- Law of independent assortment
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- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?Why was Mendel’s success dependent on his studying characteristics that exhibit only two easily distinguished phenotypes, such as white versus gray seed coats and round versus wrinkled seeds? Would he have been less successful if he had instead studied traits like seed weight or length of the leaves, which vary much more in their phenotypes? Explain your answer.
- Gregor Mendel’s basic principles of inheritance say that each trait is controlled by just one gene with just two alleles, and that each allele is clearly dominant or recessive to the other. However, we now know that many (if not most) traits are not actually inherited according to these rules. Name and describe two other (i.e., non-Mendelian) inheritance patterns, including how each one works, and a give specific example of an actual trait that follows each pattern.Why was Mendel’s success dependent on his studying characteristics that exhibit only two easily distinguished phenotypes, such as white versus gray seed coats and round versus wrinkled seeds? Would he have been less successful if he had instead studied traits such as seed weight or leaf length, which vary much more in their phenotypes? Explain your answer.Why was Mendel’s success dependent on his studying characteristics that exhibit only two easily distinguished phenotypes, such as white versus gray seed coats and round versus wrinkled seeds? Would he have been less successful if he had instead studied traits such as seed weight or leaf length, which vary much more in their phenotype?
- As you know Mendel’s main contribution to genetics was his proposing a model of particulate inheritance. This discovery contradicted the widely held belief that blending inheritance was the true theory that explained hereditary traits. One advantage that Mendel had in choosing garden peas (Pisum sativum) was that he could either allow the pea flowers on a plant to self-pollinate or he could deliberately cross-pollinate the flowers. For his single locus crosses of pure-breeding lines, he would take the F2 offspring of the dominant phenotype (such as yellow seeds) and ensure that each yellow-seeded plant would self-pollinate. He was able to show that 1/3 of all the yellow-seeded plants in this generation bred true while the other 2/3 of the yellow seeded plants showed segregation. Do you believe that this extra experiment gave additional important evidence for the particulate theory of inheritance or did the offspring from the F1 x F1 cross provide enough evidence of Mendel’s First Law?…Mendel's second postulate states: When two different unit factors responsible for a characteristic are found in the same organism, one will dominate and determine the characteristic type. Explain this postulate using modern genetic terms. Be sure to include the following terms in your explanation: dominant, recessive, allele, phenotype, genotype.In the previous topic, you learned that Gregor Mendel used Pisum sativum to conceptualize the governing laws of Genetics. In this activity, we will recall how Gregor Mendel utilized the idea of classical breeding to come up with desirable traits. Supposed you have two individual peas. One of the peas is a pure breed with round green seeds while the other has heterozygous round yellow seeds. Supposed a farmer wants to have pure breed peas that have green wrinkled seeds. How are you going to come up with these traits using the two peas that you have? (Note: If the F1 does not include a pure breed green wrinkled seed, you will use the F1 peas for next generation breeding and so on until you have the desired traits. Pure breed means homozygous alleles.) Show the Punnett squares for the cross. You will come up with two or more squares based on how many generations you made.
- Mendel describes subjecting each of the 34 varieties of peas he obtained to a two-year trial. During this time he let the plants self-fertilize and observed their offspring. What was he looking for, and what was the purpose of doing this two-year trial? Explain what Mendel means when he writes that the 3:1 ratio observed in the first generation from the hybrids "resolves itself" into a ratio of 2:1:1Shortly after the rediscovery of Mendel’s pea plant experiments, biologists began investigating whether Mendel’s laws applied to other species, as well. In England, a debate broke out about whether the color of racehorses might be governed by Mendel’s laws. Using the British Jockey Club registry of racehorse pedigrees, biologists made the following observations: A chestnut (red) stallion, when bred to chestnut mares, always produced chestnut foals. Certain black stallions, when bred to chestnut mares, produced only black foals. Other black stallions, when bred to chestnut mares, produced a mix of black foals and chestnut foals. Based on the observations described above, which color is dominant and which is recessive in the racehorses? Group of answer choices they show incomplete dominance Black; Chestnut Mix of black and chestnut is dominant (hybrid). Neither color is dominant (codominance). Chestnut, BlackA woman with fair skin, blond hair, and blue eyes gives birth to fraternal twins; the father has dark brown skin, dark hair, and brown eyes. One twin has blond hair, brown eyes, and light skin, and the other has dark hair, brown eyes, and dark skin. What Mendelian law does this real-life case illustrate and explain what this means in terms of the inherited alleles for these genes?