membrane potential as a function of time in a pacemaker cell before and after exposure to a neurotransmitter 30 15 -15 -30 -45 -60 TIME a b neurotransmitter added At time a: The funny channels are closed . The voltage gated Ca** channels are open . The voltage gated K+ channels are closed The ligand gated K+ channels are closed At time b: The funny channels are open . The voltage gated Ca** and channels are оpen The voltage gated K+ channels are closed The ligand gated K+ channels are closed Voltage below V threshold opens funny channels. Voltage above threshold opens channels that participate in the action potential. [ Select ] V drives ions through the open channels at time a. [ Select ] drives ions through the open channels at time b. Membrane potential (mv)
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The heart is made up of cardiac muscle. It contains network of specialized cardiac muscle fibers called autorhythmic fibers because they are self-excitable. They generally generate action potentials that trigger heart contractions. Cardiac action potentials normally begin in the sinoatrial node (SA node), which act as the heart's pacemaker, initiating cardiac action potentials that causes contraction of the heart. The pacemaker cell channels are also known as the funny channel, which conduct the electrical signals in the heart during contraction.
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