membrane-associated protein kinase has the sequence -GMCLVS at its C-terminus, which has been shown by mutagenesis to be essential for its biological function and sub cellular location. a) What is the most likely post-translational modification that this motif would be susceptible to? b) How is this modification introduced to the protein? c) What is the likely effect of this modification on the behaviour of the protein?
membrane-associated protein kinase has the sequence -GMCLVS at its C-terminus, which has been shown by mutagenesis to be essential for its biological function and sub cellular location. a) What is the most likely post-translational modification that this motif would be susceptible to? b) How is this modification introduced to the protein? c) What is the likely effect of this modification on the behaviour of the protein?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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A membrane-associated protein kinase has the sequence -GMCLVS at its C-terminus, which
has been shown by mutagenesis to be essential for its biological function and sub cellular
location.
a) What is the most likely post-translational modification that this motif would be
susceptible to?
b) How is this modification introduced to the protein?
c) What is the likely effect of this modification on the behaviour of the protein?
d) What other modification to N-terminus of the protein might achieve a similar
effect on the behaviour of the protein?
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