Many metabolites are maintained at steady-state concentrations that are far from equilibrium. A comparison of Keg and Q, the mass-action ratio, can determine whether a metabolic reaction is far from equilibrium. The equation for this equilibrium is, fructose 6-phosphate + ATP = fructose 1,6-bisphosphate + ADP Calculate K, for this reaction at T = 25.0 °C. AG' = -14.2 kJ/mol Ka %3D Calculate the mass-action ratio, Q , from the approximate physiological concentrations for rat heart tissue shown in the table. Metabolite Concentration (µM) Q = fructose 6-phosphate fructose 1,6-bisphosphate 84.0 29.0 ATP 11,800 ADP 1,310
Many metabolites are maintained at steady-state concentrations that are far from equilibrium. A comparison of Keg and Q, the mass-action ratio, can determine whether a metabolic reaction is far from equilibrium. The equation for this equilibrium is, fructose 6-phosphate + ATP = fructose 1,6-bisphosphate + ADP Calculate K, for this reaction at T = 25.0 °C. AG' = -14.2 kJ/mol Ka %3D Calculate the mass-action ratio, Q , from the approximate physiological concentrations for rat heart tissue shown in the table. Metabolite Concentration (µM) Q = fructose 6-phosphate fructose 1,6-bisphosphate 84.0 29.0 ATP 11,800 ADP 1,310
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:Many metabolites are maintained at steady-state concentrations that are far from equilibrium. A comparison of K, and Q,
the mass-action ratio, can determine whether a metabolic reaction is far from equilibrium.
The equation for this equilibrium is,
fructose 6-phosphate + ATP = fructose 1,6-bisphosphate + ADP
Calculate K, for this reaction at T = 25.0 °C.
AG' = -14.2 kJ/mol
Calculate the mass-action ratio, Q, from the approximate physiological concentrations for rat heart tissue shown in the table.
Metabolite
Concentration (µM)
Q =
fructose 6-phosphate
fructose 1,6-bisphosphate
84.0
29.0
ATP
11,800
ADP
1,310
Select the true statements about the PFK-1 reaction.
In heart tissue, the PFK-1 products are more abundant than reactants.
The PFK-1 reaction in heart tissue does not reach equilibrium.
In heart tissue, the PFK-1 reaction will be driven toward product formation.
Under standard conditions, the PFK-1 reaction reaches equilibrium when the concentrations of all products and reactants
are equal.
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