Lys345 abstracts a proton by general base catalysis. Two Mg2+ ions stabilize the resulting enolate intermediate. Glu211 facilitates elimination of the Mg2+ PO? Mg?+ PO -OH group by general acid catalysis. H он Mg²+- Mg2+: PO C-C-H OH OH НОН Enolase Но H но H-N-H H-N*-H 2 Lys345 Lys345 Glu211 Glu211 2-Phosphoglycerate bound to enzyme Enolate intermediate Phosphoenolpyruvate Figure 6-26a Lehninger Principles of Biochemistry, Sixth Edition © 2013 W. H. Freeman and Company =
Lys345 abstracts a proton by general base catalysis. Two Mg2+ ions stabilize the resulting enolate intermediate. Glu211 facilitates elimination of the Mg2+ PO? Mg?+ PO -OH group by general acid catalysis. H он Mg²+- Mg2+: PO C-C-H OH OH НОН Enolase Но H но H-N-H H-N*-H 2 Lys345 Lys345 Glu211 Glu211 2-Phosphoglycerate bound to enzyme Enolate intermediate Phosphoenolpyruvate Figure 6-26a Lehninger Principles of Biochemistry, Sixth Edition © 2013 W. H. Freeman and Company =
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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In what type of catalysis does Lys345 engage during the very first step of enolase's reaction cycle? Explain, in your own words, specifically why and how Lys345 falls into the category you chose.
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