List three types of chemical reactions that prepare drug molecules for excretion from the body.
List three types of chemical reactions that prepare drug molecules for excretion from the body.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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List three types of
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Biotransformation causes a chemical alteration of a drug within the body. It is the conversion of drug molecule to more water-soluble molecules. Liver is the predominantly site for drug metabolism. Although metabolism inactivates the drugs, but some drug metabolites are pharmacologically active and they are known as prodrug.
The kidneys cannot efficiently excrete highly fat soluble drugs that readily cross cell membranes as they reabsorbed in the last stages of filtration. These compounds must first be metabolized in the liver to more water-soluble compounds and the removed from the body
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