(-)-Lepadiformine A, isolated from the marine organism Clavelina lepadiformis, is observed to be toxic to several tumor cell lines. During a recent synthesis of (-)-lepadiformine A, compound 3 was made from compounds 1 and 2. مین میں ہے میں نے OR Identify reagents that can be used to prepare 3 from 1 and 2. The terminal alkyne (compound 2) must be Also, the alcohol (compound 1) must be converted into a of these reactions will result in an SN with a reaction, giving compound 3. OR OR to convert it into a OH + OR ✓. For example, the alcohol can be treated with (using, for example, ✓ Combining products

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Q: Mass Spectrum 120 100 80 24 41 56 57 10 15 20 25 30 35 40 45 50 55 60 65 70 m/z Relative Intensity

A:

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A:

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Organomagnesium compounds

The interaction of alkyl halide with Mg metal in a suitable ether solvent is the common method for the synthesis of the Grignard reagent.

Hydrolysis Grignard Reactions and Reduction

Organomagnesium halides are Grignard reagents. Francois Auguste Victor Grignard, a French chemist who received the Nobel Prize in Chemistry in 1912, created these highly useful reagents.