L-lactate is constantly produced from pyruvate via the enzyme lactate dehydrogenase (LDH) in a process of fermentation during normal metabolism and exercise. It can pick up a proton and become lactic acid(see right). The pKa of lactic acid is 3.86. A) Identify the ionizable oxygen that is partially protonated (50 % dissociated) at pH=3.86. B) Determine the acid dissociation constant, (Ka)?

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L-lactate is constantly produced from pyruvate via
the enzyme lactate dehydrogenase (LDH) in a
process of fermentation during normal metabolism
and exercise. It can pick up a proton and become
lactic acid(see right). The pK, of lactic acid is 3.86.
A) Identify the ionizable oxygen that is partially
protonated (50 % dissociated) at pH=3.86.
ÕH
B) Determine the acid dissociation constant, (Ka)?
Transcribed Image Text:L-lactate is constantly produced from pyruvate via the enzyme lactate dehydrogenase (LDH) in a process of fermentation during normal metabolism and exercise. It can pick up a proton and become lactic acid(see right). The pK, of lactic acid is 3.86. A) Identify the ionizable oxygen that is partially protonated (50 % dissociated) at pH=3.86. ÕH B) Determine the acid dissociation constant, (Ka)?
Expert Solution
Step 1

For the above mentioned chemical situation:, equation is given below:

lactic acid (aq) + H2O (l)  lactate ion (aq) + H3O+ (aq)Henderson-Hasselbalch equation pH = pKa + loglactate ionlactic acid3.86-3.86= loglactate ionlactic acidanti-log(0)=lactate ionlactic acidLactate ion = Lactic acid

The ionizable oxygen is the one attached to carboxylic acid group (pka near 4) being more acidic in nature than the corresponding alcohol group( pka near 15).

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