L-lactate is constantly produced from pyruvate viathe enzyme lactate dehydrogenase (LDH) in aprocess of fermentation during normal metabolismand exercise. It can pick up a proton and becomelactic acid(see right). The pK, of lactic acid is 3.86.A) Identify the ionizable oxygen that is partiallyprotonated (50 % dissociated) at pH=3.86.ÕHB) Determine the acid dissociation constant, (Ka)?

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Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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L-lactate is constantly produced from pyruvate via
the enzyme lactate dehydrogenase (LDH) in a
process of fermentation during normal metabolism
and exercise. It can pick up a proton and become
lactic acid(see right). The pK, of lactic acid is 3.86.
A) Identify the ionizable oxygen that is partially
protonated (50 % dissociated) at pH=3.86.
ÕH
B) Determine the acid dissociation constant, (Ka)?

Expert Solution

Step 1

For the above mentioned chemical situation:, equation is given below:

$lactic acid (aq) + H_{2} O (l) ⇌ lactate ion (aq) + H_{3} O^{+} (aq) Henderson - Hasselbalch equation pH = pKa + \log (\frac{lactate ion}{lactic acid}) 3.86 - 3.86 = \log (\frac{lactate ion}{lactic acid}) anti - \log (0) = (\frac{lactate ion}{lactic acid}) [Lactate ion] = [Lactic acid]$

The ionizable oxygen is the one attached to carboxylic acid group (pka near 4) being more acidic in nature than the corresponding alcohol group( pka near 15).

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