L-Dopa (Levodopa) is an oral medication used to treat Parkinson's disease, the symptoms of which result from a lack of dopamine in the brain. L-Dopa relies on L-type, or leucine-preferring, transport proteins to cross the blood-brain barrier, and it is converted to dopamine in the brain by the enzyme aromatic-L-amino-acid decarboxylase. Properties of L-Dopa: • density: 1.47 g/cm melting point: 278 °C • boiling point: decomposes solubility in water: low solubility • solubility in lipids: low solubility • rotates plane-polarized light counterclockwise Classify each property based on whether it is or is not a property of
L-Dopa (Levodopa) is an oral medication used to treat Parkinson's disease, the symptoms of which result from a lack of dopamine in the brain. L-Dopa relies on L-type, or leucine-preferring, transport proteins to cross the blood-brain barrier, and it is converted to dopamine in the brain by the enzyme aromatic-L-amino-acid decarboxylase. Properties of L-Dopa: • density: 1.47 g/cm melting point: 278 °C • boiling point: decomposes solubility in water: low solubility • solubility in lipids: low solubility • rotates plane-polarized light counterclockwise Classify each property based on whether it is or is not a property of
Human Anatomy & Physiology (11th Edition)
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ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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![L-Dopa (Levodopa) is an oral medication used to treat Parkinson's disease, the symptoms of which result from a lack of dopamine in the brain. L-Dopa relies on L-type, or leucine-preferring, transport proteins to cross the blood-brain barrier, and it is converted to dopamine in the brain by the enzyme aromatic-L-amino-acid decarboxylase.
Properties of L-Dopa:
- **Density**: 1.47 g/cm³
- **Melting Point**: 278 °C
- **Boiling Point**: Decomposes
- **Solubility in Water**: Low solubility
- **Solubility in Lipids**: Low solubility
- **Optical Activity**: Rotates plane-polarized light counterclockwise
Classify each property based on whether it is or is not a property of L-Dopa's enantiomer, D-Dopa.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F28000c02-e2c6-4a8b-b2f9-904011bfd87b%2Fa30883f1-668a-45c4-9146-5183e09f759f%2Fucavjv5_processed.png&w=3840&q=75)
Transcribed Image Text:L-Dopa (Levodopa) is an oral medication used to treat Parkinson's disease, the symptoms of which result from a lack of dopamine in the brain. L-Dopa relies on L-type, or leucine-preferring, transport proteins to cross the blood-brain barrier, and it is converted to dopamine in the brain by the enzyme aromatic-L-amino-acid decarboxylase.
Properties of L-Dopa:
- **Density**: 1.47 g/cm³
- **Melting Point**: 278 °C
- **Boiling Point**: Decomposes
- **Solubility in Water**: Low solubility
- **Solubility in Lipids**: Low solubility
- **Optical Activity**: Rotates plane-polarized light counterclockwise
Classify each property based on whether it is or is not a property of L-Dopa's enantiomer, D-Dopa.
![**Properties of D-Dopa**
- **Rotates plane-polarized light clockwise:** This refers to D-Dopa's ability to change the direction of plane-polarized light, a common characteristic in stereochemistry used to identify specific configurations.
- **Highly soluble in water:** D-Dopa dissolves well in water, indicating its hydrophilic nature.
- **Density slightly less than that of L-Dopa:** This suggests that D-Dopa and L-Dopa have different packing arrangements or molecular interactions.
- **Solid at room temperature:** D-Dopa exists in solid form under standard room temperature conditions.
**Not a Property of D-Dopa**
- **Reduces symptoms of Parkinson's disease:** Unlike L-Dopa, which is used as a treatment for Parkinson’s disease, D-Dopa does not have this therapeutic effect.
- **Aromatic-L-amino-acid decarboxylase has a different affinity for D-Dopa:** This enzyme interacts differently with D-Dopa compared to L-Dopa, affecting how it is metabolized.
- **Good substrate for aromatic-L-amino-acid decarboxylase:** D-Dopa is not efficiently processed by this enzyme, unlike L-Dopa, which is a better substrate.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F28000c02-e2c6-4a8b-b2f9-904011bfd87b%2Fa30883f1-668a-45c4-9146-5183e09f759f%2F0xo5lws_processed.png&w=3840&q=75)
Transcribed Image Text:**Properties of D-Dopa**
- **Rotates plane-polarized light clockwise:** This refers to D-Dopa's ability to change the direction of plane-polarized light, a common characteristic in stereochemistry used to identify specific configurations.
- **Highly soluble in water:** D-Dopa dissolves well in water, indicating its hydrophilic nature.
- **Density slightly less than that of L-Dopa:** This suggests that D-Dopa and L-Dopa have different packing arrangements or molecular interactions.
- **Solid at room temperature:** D-Dopa exists in solid form under standard room temperature conditions.
**Not a Property of D-Dopa**
- **Reduces symptoms of Parkinson's disease:** Unlike L-Dopa, which is used as a treatment for Parkinson’s disease, D-Dopa does not have this therapeutic effect.
- **Aromatic-L-amino-acid decarboxylase has a different affinity for D-Dopa:** This enzyme interacts differently with D-Dopa compared to L-Dopa, affecting how it is metabolized.
- **Good substrate for aromatic-L-amino-acid decarboxylase:** D-Dopa is not efficiently processed by this enzyme, unlike L-Dopa, which is a better substrate.
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