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L-Dopa (Levodopa) is an oral medication used to treat Parkinson's disease, the symptoms of which result from a lack of dopamine in the brain. L-Dopa relies on L-type, or leucine-preferring, transport proteins to cross the blood-brain barrier, and it is converted to dopamine in the brain by the enzyme aromatic-L-amino-acid decarboxylase. Properties of L-Dopa: • density: 1.47 g/cm melting point: 278 °C • boiling point: decomposes solubility in water: low solubility • solubility in lipids: low solubility • rotates plane-polarized light counterclockwise Classify each property based on whether it is or is not a property of

L-Dopa (Levodopa) is an oral medication used to treat Parkinson's disease, the symptoms of which result from a lack of dopamine in the brain. L-Dopa relies on L-type, or leucine-preferring, transport proteins to cross the blood-brain barrier, and it is converted to dopamine in the brain by the enzyme aromatic-L-amino-acid decarboxylase. Properties of L-Dopa: • density: 1.47 g/cm melting point: 278 °C • boiling point: decomposes solubility in water: low solubility • solubility in lipids: low solubility • rotates plane-polarized light counterclockwise Classify each property based on whether it is or is not a property of

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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L-Dopa (Levodopa) is an oral medication used to treat Parkinson's disease, the symptoms of which result from a lack of dopamine in the brain. L-Dopa relies on L-type, or leucine-preferring, transport proteins to cross the blood-brain barrier, and it is converted to dopamine in the brain by the enzyme aromatic-L-amino-acid decarboxylase. Properties of L-Dopa: - **Density**: 1.47 g/cm³ - **Melting Point**: 278 °C - **Boiling Point**: Decomposes - **Solubility in Water**: Low solubility - **Solubility in Lipids**: Low solubility - **Optical Activity**: Rotates plane-polarized light counterclockwise Classify each property based on whether it is or is not a property of L-Dopa's enantiomer, D-Dopa.
Transcribed Image Text:L-Dopa (Levodopa) is an oral medication used to treat Parkinson's disease, the symptoms of which result from a lack of dopamine in the brain. L-Dopa relies on L-type, or leucine-preferring, transport proteins to cross the blood-brain barrier, and it is converted to dopamine in the brain by the enzyme aromatic-L-amino-acid decarboxylase. Properties of L-Dopa: - **Density**: 1.47 g/cm³ - **Melting Point**: 278 °C - **Boiling Point**: Decomposes - **Solubility in Water**: Low solubility - **Solubility in Lipids**: Low solubility - **Optical Activity**: Rotates plane-polarized light counterclockwise Classify each property based on whether it is or is not a property of L-Dopa's enantiomer, D-Dopa.
**Properties of D-Dopa** - **Rotates plane-polarized light clockwise:** This refers to D-Dopa's ability to change the direction of plane-polarized light, a common characteristic in stereochemistry used to identify specific configurations. - **Highly soluble in water:** D-Dopa dissolves well in water, indicating its hydrophilic nature. - **Density slightly less than that of L-Dopa:** This suggests that D-Dopa and L-Dopa have different packing arrangements or molecular interactions. - **Solid at room temperature:** D-Dopa exists in solid form under standard room temperature conditions. **Not a Property of D-Dopa** - **Reduces symptoms of Parkinson's disease:** Unlike L-Dopa, which is used as a treatment for Parkinson’s disease, D-Dopa does not have this therapeutic effect. - **Aromatic-L-amino-acid decarboxylase has a different affinity for D-Dopa:** This enzyme interacts differently with D-Dopa compared to L-Dopa, affecting how it is metabolized. - **Good substrate for aromatic-L-amino-acid decarboxylase:** D-Dopa is not efficiently processed by this enzyme, unlike L-Dopa, which is a better substrate.
Transcribed Image Text:**Properties of D-Dopa** - **Rotates plane-polarized light clockwise:** This refers to D-Dopa's ability to change the direction of plane-polarized light, a common characteristic in stereochemistry used to identify specific configurations. - **Highly soluble in water:** D-Dopa dissolves well in water, indicating its hydrophilic nature. - **Density slightly less than that of L-Dopa:** This suggests that D-Dopa and L-Dopa have different packing arrangements or molecular interactions. - **Solid at room temperature:** D-Dopa exists in solid form under standard room temperature conditions. **Not a Property of D-Dopa** - **Reduces symptoms of Parkinson's disease:** Unlike L-Dopa, which is used as a treatment for Parkinson’s disease, D-Dopa does not have this therapeutic effect. - **Aromatic-L-amino-acid decarboxylase has a different affinity for D-Dopa:** This enzyme interacts differently with D-Dopa compared to L-Dopa, affecting how it is metabolized. - **Good substrate for aromatic-L-amino-acid decarboxylase:** D-Dopa is not efficiently processed by this enzyme, unlike L-Dopa, which is a better substrate.
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