It takes time to get the hang of R and S - and practice. For this activity determine R or S for each of the following molecules. Br H. 1. 2. -C.... Br CI- CH3 CN 3. 4. CCH, NH, CH H POH CH

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**Chirality in Organic Molecules**

It takes time to get the hang of R and S configurations—and practice. For this activity, determine R or S for each of the following molecules.

1. **Molecule 1 Structure:**
   - Central carbon is bonded to fluorine (F), iodine (I), bromine (Br), and hydrogen (H).

2. **Molecule 2 Structure:**
   - Central carbon is bonded to bromine (Br), chlorine (Cl), a methyl group (CH₃), and hydrogen (H).

3. **Molecule 3 Structure:**
   - Central carbon is bonded to sulfur (S), a methyl group (CH₃), and two hydrogens (H).

4. **Molecule 4 Structure:**
   - Central carbon is bonded to a cyanide group (CN), an amino group (CH₂NH₂), hydroxyl group (OH), and hydrogen (H).

5. **Molecule 5 Structure:**
   - Central carbon is bonded to a carboxylic acid group (COOH), hydroxymethyl group (HOH₂C), and two hydrogens (H).

**Instructions**

For each of the molecules, determine R or S and give the groups in order of priority from highest to lowest using greater than signs between them. For example, it would look like: S, OH > NH₂ > CH₃. 

Please apply the Cahn-Ingold-Prelog priority rules to assign priorities to the groups, then use these priorities to identify whether each chiral center has an R or S configuration.
Transcribed Image Text:**Chirality in Organic Molecules** It takes time to get the hang of R and S configurations—and practice. For this activity, determine R or S for each of the following molecules. 1. **Molecule 1 Structure:** - Central carbon is bonded to fluorine (F), iodine (I), bromine (Br), and hydrogen (H). 2. **Molecule 2 Structure:** - Central carbon is bonded to bromine (Br), chlorine (Cl), a methyl group (CH₃), and hydrogen (H). 3. **Molecule 3 Structure:** - Central carbon is bonded to sulfur (S), a methyl group (CH₃), and two hydrogens (H). 4. **Molecule 4 Structure:** - Central carbon is bonded to a cyanide group (CN), an amino group (CH₂NH₂), hydroxyl group (OH), and hydrogen (H). 5. **Molecule 5 Structure:** - Central carbon is bonded to a carboxylic acid group (COOH), hydroxymethyl group (HOH₂C), and two hydrogens (H). **Instructions** For each of the molecules, determine R or S and give the groups in order of priority from highest to lowest using greater than signs between them. For example, it would look like: S, OH > NH₂ > CH₃. Please apply the Cahn-Ingold-Prelog priority rules to assign priorities to the groups, then use these priorities to identify whether each chiral center has an R or S configuration.
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