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Is there significant evidence of a difference in elimination half-life depending on drug dosage? State hypotheses for the test (μ₁ and μ₂ are the means for 1 mg and 2 mg respectively).

Is there significant evidence of a difference in elimination half-life depending on drug dosage? State hypotheses for the test (μ₁ and μ₂ are the means for 1 mg and 2 mg respectively).

MATLAB: An Introduction with Applications
MATLAB: An Introduction with Applications
6th Edition
ISBN:9781119256830
Author:Amos Gilat
Publisher:Amos Gilat
Chapter1: Starting With Matlab
Section: Chapter Questions
Problem 1P
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18.32 (EX) More on pharmacokinetics 1/3: The following exercise is based on summary statistics rather than raw data. This information is typically all that is presented in published reports. Inference procedures can be calculated by hand from the summaries. You must trust that the authors understood the conditions for inference and verified that they apply. This isn't always true. Avandia (rosiglitazone maleate) is an oral antidiabetic drug produced by the pharmaceutical company GlaxoSmithKline. Before a drug can be prescribed, we must know how the body absorbs and excretes it. Patients were given a single dose of either 1 mg or 2 mg of rosiglitazone, and the maximum plasma concentration of the drug (in ng/ml) was assessed. The study also looked at how fast the body gets rid of the drug by measuring the elimination half-life (in hours). Here are the results. Treatment n mean standard deviation 1 mg 32 3.16 0.72 2 mg 32 3.15 0.39 Is there significant evidence of a difference in elimination half-life depending on drug dosage? State hypotheses for the test (μ₁ and µ₂ are the means for 1 mg and 2 mg respectively). O Ho: H1 H2 vs. H₂: H₁> H₂ Ho: H₁ H₂ VS. H₂ : H₁ H₂ O Ho: H1 H2 vs. Ha : H1 = H₂ O Ho: H1 H2 Vs. Ha : H1 H₂
Transcribed Image Text:18.32 (EX) More on pharmacokinetics 1/3: The following exercise is based on summary statistics rather than raw data. This information is typically all that is presented in published reports. Inference procedures can be calculated by hand from the summaries. You must trust that the authors understood the conditions for inference and verified that they apply. This isn't always true. Avandia (rosiglitazone maleate) is an oral antidiabetic drug produced by the pharmaceutical company GlaxoSmithKline. Before a drug can be prescribed, we must know how the body absorbs and excretes it. Patients were given a single dose of either 1 mg or 2 mg of rosiglitazone, and the maximum plasma concentration of the drug (in ng/ml) was assessed. The study also looked at how fast the body gets rid of the drug by measuring the elimination half-life (in hours). Here are the results. Treatment n mean standard deviation 1 mg 32 3.16 0.72 2 mg 32 3.15 0.39 Is there significant evidence of a difference in elimination half-life depending on drug dosage? State hypotheses for the test (μ₁ and µ₂ are the means for 1 mg and 2 mg respectively). O Ho: H1 H2 vs. H₂: H₁> H₂ Ho: H₁ H₂ VS. H₂ : H₁ H₂ O Ho: H1 H2 vs. Ha : H1 = H₂ O Ho: H1 H2 Vs. Ha : H1 H₂
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