IPSCs are nearly identical to human embryonic stemcells in terms of gene expression, but there may be otherways in which they are not equivalent. For example, thetelomeres of IPSCs often vary in length, with many IPSCscells having telomeres shorter than those of embryonic.How might shortened telomeres affect the life-span ofIPSCs or of differentiated cells derived from them?
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
IPSCs are nearly identical to human embryonic stem
cells in terms of gene expression, but there may be other
ways in which they are not equivalent. For example, the
telomeres of IPSCs often vary in length, with many IPSCs
cells having telomeres shorter than those of embryonic.
How might shortened telomeres affect the life-span of
IPSCs or of differentiated cells derived from them?
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