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Inhibitory post synaptic membrane potential - Data Cl- Cl- Nr of GABA Max Postsynaptic Voltage (mV) inside outside receptors 10 140 20 -68-774 100 140 20 - 34.428 10 140 40 -68.776 Questions 11. What is an IPSP? 12. GABA receptors on the postsynaptic neuron function as ion channels for which ion?

Inhibitory post synaptic membrane potential - Data Cl- Cl- Nr of GABA Max Postsynaptic Voltage (mV) inside outside receptors 10 140 20 -68-774 100 140 20 - 34.428 10 140 40 -68.776 Questions 11. What is an IPSP? 12. GABA receptors on the postsynaptic neuron function as ion channels for which ion?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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### Inhibitory Post Synaptic Membrane Potential - Data #### Table: | Cl- inside | Cl- outside | Nr of GABA receptors | Max Postsynaptic Voltage (mV) | |------------|-------------|----------------------|-------------------------------| | 10 | 140 | 20 | -68.774 | | 100 | 140 | 20 | -34.428 | | 10 | 140 | 40 | -68.776 | --- ### Questions **11. What is an IPSP?** --- **12. GABA receptors on the postsynaptic neuron function as ion channels for which ion?** --- **13. Based on the data collected, when is it more possible for an action potential to occur? When the intracellular Cl- concentration in the postsynaptic neuron increases or when the number of GABA receptors on the postsynaptic membrane increases?** --- **14. Explain** ---
Transcribed Image Text:### Inhibitory Post Synaptic Membrane Potential - Data #### Table: | Cl- inside | Cl- outside | Nr of GABA receptors | Max Postsynaptic Voltage (mV) | |------------|-------------|----------------------|-------------------------------| | 10 | 140 | 20 | -68.774 | | 100 | 140 | 20 | -34.428 | | 10 | 140 | 40 | -68.776 | --- ### Questions **11. What is an IPSP?** --- **12. GABA receptors on the postsynaptic neuron function as ion channels for which ion?** --- **13. Based on the data collected, when is it more possible for an action potential to occur? When the intracellular Cl- concentration in the postsynaptic neuron increases or when the number of GABA receptors on the postsynaptic membrane increases?** --- **14. Explain** ---
### Activity 4: Integration 1. **Add Synapses:** - In the settings, add (+) 3 synapses to the neuron. Ensure all synapses are EPSP. 2. **Create Simulation:** - Click on "Create Simulation." 3. **Run the Simulation:** - Press the play button (▶️). 4. **Record Voltage:** - Note the membrane voltage value. 5. **Access Settings:** - Click on the back button to access the settings menu. 6. **Modify Synapse 1:** - In the settings, change Synapse 1 to IPSP and adjust the number of receptors to 5. 7. **Repeat:** - Repeat steps 2-5. #### Observations: | Synapse 1 | Synapse 2 | Synapse 3 | Max Axon Hillock Voltage (mV) | Is an action potential fired? (yes/no) | |------------------|------------------|------------------|------------------------------|------------------------------------| | EPSP / 20 receptors | EPSP / 20 receptors | EPSP / 20 receptors | -70.208 mV | Yes | | IPSP / 5 receptors | EPSP / 20 receptors | EPSP / 20 receptors | -78.972 mV | Yes | #### Questions: 15. **Post-Synaptic Neuron Firing:** - In which area of a post-synaptic neuron is an action potential fired? Why? 16. **Temporal vs. Spatial Summation:** - Explain the difference between temporal and spatial summation. 17. **Type of Summation:** - Which of the above types is present in this experiment? 18. **Changing Experimental Parameters:** - Given that Synapse 1 causes IPSPs, state two experimental parameters that you would change, so that an action potential was possible. --- (Note: The table provides data on synaptic configurations and resulting membrane potentials along with action potential outcomes. Analyze the table for information related to synaptic integration and action potential firing.)
Transcribed Image Text:### Activity 4: Integration 1. **Add Synapses:** - In the settings, add (+) 3 synapses to the neuron. Ensure all synapses are EPSP. 2. **Create Simulation:** - Click on "Create Simulation." 3. **Run the Simulation:** - Press the play button (▶️). 4. **Record Voltage:** - Note the membrane voltage value. 5. **Access Settings:** - Click on the back button to access the settings menu. 6. **Modify Synapse 1:** - In the settings, change Synapse 1 to IPSP and adjust the number of receptors to 5. 7. **Repeat:** - Repeat steps 2-5. #### Observations: | Synapse 1 | Synapse 2 | Synapse 3 | Max Axon Hillock Voltage (mV) | Is an action potential fired? (yes/no) | |------------------|------------------|------------------|------------------------------|------------------------------------| | EPSP / 20 receptors | EPSP / 20 receptors | EPSP / 20 receptors | -70.208 mV | Yes | | IPSP / 5 receptors | EPSP / 20 receptors | EPSP / 20 receptors | -78.972 mV | Yes | #### Questions: 15. **Post-Synaptic Neuron Firing:** - In which area of a post-synaptic neuron is an action potential fired? Why? 16. **Temporal vs. Spatial Summation:** - Explain the difference between temporal and spatial summation. 17. **Type of Summation:** - Which of the above types is present in this experiment? 18. **Changing Experimental Parameters:** - Given that Synapse 1 causes IPSPs, state two experimental parameters that you would change, so that an action potential was possible. --- (Note: The table provides data on synaptic configurations and resulting membrane potentials along with action potential outcomes. Analyze the table for information related to synaptic integration and action potential firing.)
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