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A End-plate potential Current B 4 = 0 Extracellular side Time 1 Steady state EPSP = 0 Channels in synaptic membrane GEPSP EEPSP (0 mV) 1=0 O Channels in nonsynaptic membrane E (-90 mV) EPSP Cytoplasmic side Time 2 Dynamic (onset of synaptic action) EPSP=+1 Extracellular side EPSP EEPSP E Cytoplasmic side O The EPSP would get smaller in amplitude the capacitive current would be twice as big O The EPSP would last longer Time 3 Steady state (peak of synaptic action) the leak current would be smaller EPSP = 1=0 Extracellular side EPSP EEPSP E₁ Cytoplasmic side 2 ms 10 mV Time 4 Dynamic (decline of synaptic action) EPSP = 0 Extracellular side EEPSP If the same IEPSP was present in a cell that had twice as much membrane capacitance but was otherwise the same, what would NOT happen? E Cytoplasmic side

A End-plate potential Current B 4 = 0 Extracellular side Time 1 Steady state EPSP = 0 Channels in synaptic membrane GEPSP EEPSP (0 mV) 1=0 O Channels in nonsynaptic membrane E (-90 mV) EPSP Cytoplasmic side Time 2 Dynamic (onset of synaptic action) EPSP=+1 Extracellular side EPSP EEPSP E Cytoplasmic side O The EPSP would get smaller in amplitude the capacitive current would be twice as big O The EPSP would last longer Time 3 Steady state (peak of synaptic action) the leak current would be smaller EPSP = 1=0 Extracellular side EPSP EEPSP E₁ Cytoplasmic side 2 ms 10 mV Time 4 Dynamic (decline of synaptic action) EPSP = 0 Extracellular side EEPSP If the same IEPSP was present in a cell that had twice as much membrane capacitance but was otherwise the same, what would NOT happen? E Cytoplasmic side

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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### Description #### Part A: Graph of End-Plate Potential and Current - **End-Plate Potential (Red Line)** - The graph shows a plot of end-plate potential over time, marked by four phases: 1. Initial phase 2. Rising phase 3. Peak phase 4. Decline phase - The potential is measured in millivolts (mV) and the time duration is represented over 2 milliseconds (ms). - **Current (Purple Line)** - The current graph shows two main components: capacitive current (Ic) and leak current (Il). - I_EPSP is also marked and reflects excitatory postsynaptic potential-related current. #### Part B: Circuit Models at Different Times - **Time 1: Steady State (I_EPSP = 0)** - Represented by open channels in the synaptic membrane. - The intracellular side is marked with E_EPSP and I_EPSP = 0. - **Time 2: Dynamic (Onset of Synaptic Action)** - I_EPSP is the sum of Ic and Il. - Circuit shows movement of ions across channels and capacitors representing membrane capacitance (C_m). - **Time 3: Steady State (Peak of Synaptic Action)** - I_EPSP equals Il, Ic = 0. - Voltage across the membrane (E_i). - **Time 4: Dynamic (Decline of Synaptic Action)** - I_EPSP consists of -Ic and Il. - Similar circuit model as Time 2. ### Question If the same I_EPSP was present in a cell that had twice as much membrane capacitance but was otherwise the same, what would NOT happen? - The EPSP would get smaller in amplitude - The capacitive current would be twice as big - The EPSP would last longer - The leak current would be smaller
Transcribed Image Text:### Description #### Part A: Graph of End-Plate Potential and Current - **End-Plate Potential (Red Line)** - The graph shows a plot of end-plate potential over time, marked by four phases: 1. Initial phase 2. Rising phase 3. Peak phase 4. Decline phase - The potential is measured in millivolts (mV) and the time duration is represented over 2 milliseconds (ms). - **Current (Purple Line)** - The current graph shows two main components: capacitive current (Ic) and leak current (Il). - I_EPSP is also marked and reflects excitatory postsynaptic potential-related current. #### Part B: Circuit Models at Different Times - **Time 1: Steady State (I_EPSP = 0)** - Represented by open channels in the synaptic membrane. - The intracellular side is marked with E_EPSP and I_EPSP = 0. - **Time 2: Dynamic (Onset of Synaptic Action)** - I_EPSP is the sum of Ic and Il. - Circuit shows movement of ions across channels and capacitors representing membrane capacitance (C_m). - **Time 3: Steady State (Peak of Synaptic Action)** - I_EPSP equals Il, Ic = 0. - Voltage across the membrane (E_i). - **Time 4: Dynamic (Decline of Synaptic Action)** - I_EPSP consists of -Ic and Il. - Similar circuit model as Time 2. ### Question If the same I_EPSP was present in a cell that had twice as much membrane capacitance but was otherwise the same, what would NOT happen? - The EPSP would get smaller in amplitude - The capacitive current would be twice as big - The EPSP would last longer - The leak current would be smaller
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