Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
![**Question:**
Indicate the major organic product from the reaction shown.
**Reaction Details:**
- **Reaction Components:**
- A primary amine is depicted on the left side of the reaction, characterized by an NH group attached to a single carbon with two additional branches extending from the carbon.
- A carboxylic acid is depicted on the right side of the amine, characterized by an OH group and a carbonyl group (C=O) attached to a cyclohexane ring.
- **Reagent:**
- DCC (Dicyclohexylcarbodiimide) is the reagent used, represented by an arrow pointing right.
**Explanation:**
This reaction illustrates the synthesis of an amide using the carboxylic acid and amine through the activation of the carboxylic acid by DCC. The major product of this reaction will be an amide formed by the condensation of the amine and the carboxylic acid. The DCC facilitates the formation of a peptide bond by converting the carboxylic acid into a more reactive intermediate, which readily reacts with the amine to form the amide.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F9b09f075-62f8-4fdf-8a55-89b8bcc8d5b4%2F905f8705-7640-4c49-986b-533b9e01a712%2Fcal4wyo_processed.jpeg&w=3840&q=75)
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