In your attempts to identify a genetic basis for rheumatoid arthritis in humans, you have DNA samples from three large unrelated families in which individuals with varying severity of rheumatoid arthritis are found. From your analysis of various SNPs, you find that the same four unlinked loci consistently show a correlation with the most severe cases from all three families. Based on your observations, which of the following hypotheses best describes the genetic control of rheumatoid arthritis? O Rheumatoid arthritis is the result of phenocopy by the environment O Different genes regulate the disease in different families O Rheumatoid arthritis is controlled by a single X-linked recessive trait O Rheumatoid arthritis is controlled by polygenic (or quantitative) traits Rheumatoid arthritis is controlled by a single autosomal dominant trait

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