In Ullrich et al. (2022), the authors describe that the different Covid variants have "missense" mutations. What are missense mutations? Conformational changes in enzymes The substitution of amino acid in the protein Mutations that occur directly to the enzyme's active site that results in substrates not being able to bind The substitution of the non-amino acid atoms or molecules that are permanently attached to proteins called prosthetic groups
Genetic Recombination
Recombination is crucial to this process because it allows genes to be reassorted into diverse combinations. Genetic recombination is the process of combining genetic components from two different origins into a single unit. In prokaryotes, genetic recombination takes place by the unilateral transfer of deoxyribonucleic acid. It includes transduction, transformation, and conjugation. The genetic exchange occurring between homologous deoxyribonucleic acid sequences (DNA) from two different sources is termed general recombination. For this to happen, an identical sequence of the two recombining molecules is required. The process of genetic exchange which occurs in eukaryotes during sexual reproduction such as meiosis is an example of this type of genetic recombination.
Microbial Genetics
Genes are the functional units of heredity. They transfer characteristic information from parents to the offspring.
Mutation is any change in the DNA sequence that can altered the final gene product. In some cases mutation will not alter the final gene product. According to nature mutations can be classified as- numerical aberrations or structural aberrations.
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