In the technique of high performance liquid chromatography (HPLC) the peak area response for a particular analyte is directly proportional to concentration Analgesic tablets typically consist of aspirin and caffeine as the active ingredients, the remainder made up of inert binding material. The concentrations of aspirin and caffeine may be routinely monitored using HPLC, whereby the peak areas obtained from a solution of the tablet are compared with those obtained from standard solutions of the analytes In an analysis to determine the concentration of caffeine in such a tablet, the following data were recorded: Solutions Analysed: Tablet Sample: Caffeine Standard: HPLC results: Mass of tablet (dissolved in 250 cm methanol: 0.523 g Mass of caffeine (dissolved in 500 cm methanol) 0.105g Solution Peak Area (caffeine) 1. Tablet Sample 325 2. Caffeine Std. 865 The conrentr ablet (expressed as a mass (ww percentage) was
In the technique of high performance liquid chromatography (HPLC) the peak area response for a particular analyte is directly proportional to concentration Analgesic tablets typically consist of aspirin and caffeine as the active ingredients, the remainder made up of inert binding material. The concentrations of aspirin and caffeine may be routinely monitored using HPLC, whereby the peak areas obtained from a solution of the tablet are compared with those obtained from standard solutions of the analytes In an analysis to determine the concentration of caffeine in such a tablet, the following data were recorded: Solutions Analysed: Tablet Sample: Caffeine Standard: HPLC results: Mass of tablet (dissolved in 250 cm methanol: 0.523 g Mass of caffeine (dissolved in 500 cm methanol) 0.105g Solution Peak Area (caffeine) 1. Tablet Sample 325 2. Caffeine Std. 865 The conrentr ablet (expressed as a mass (ww percentage) was
Chapter14: Chromatography
Section: Chapter Questions
Problem 9P
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