In the RBCs of the patient described above, which of the following would be expected? And give the explanation. (3 sentences) ADP to ATP ratios would be elevated above normal. NADP+ would increase relative to NADPH. Ribulose 5-phosphate levels would decrease. NADH to NAD+ ratios would decrease. Methemoglobin levels would increase.
A 2-year-old black girl is being seen by the hematologist after her pediatrician found her to be severely anemic with splenomegaly and jaundice. Her mother gives a possible history of a “blood problem” in her family but doesn’t know for sure. Her hemoglobin electrophoresis was normal, and the complete blood count (CBC) revealed a normocytic anemia. The platelet and white blood cell counts are normal. On the peripheral smear, there are many bizarre erythrocytes, including spiculated cells. A diagnosis of pyruvate kinase deficiency is made.
In the RBCs of the patient described above, which of the following would be expected? And give the explanation. (3 sentences)
- ADP to ATP ratios would be elevated above normal.
- NADP+ would increase relative to NADPH.
- Ribulose 5-phosphate levels would decrease.
- NADH to NAD+ ratios would decrease.
- Methemoglobin levels would increase.
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In the RBCs of the patient described above, which ONE of the following listed below would be expected? And give the explanation. (3 sentences)
- ADP to ATP ratios would be elevated above normal.
- NADP+ would increase relative to NADPH.
- Ribulose 5-phosphate levels would decrease.
- NADH to NAD+ ratios would decrease.
- Methemoglobin levels would increase.
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