In the figure below, His carries out generates| tetrahedral intermediate is stabilized by the by accepting a proton from the serine hydroxyl sidechain. This the carbonyl carbon of the sessile bond. The formed to Choose from: SN1, electrophilic attack, oxyanion hole, nucleophilic attack, alkoxide, hydrophobic pocket, hydrophilic pocket, general base catalysis, and genemal acid catalysis. His Asp (102) 57 CH2 H2C Ser 195 1 CH2 R' Substrate N-C polypeptide H.
In the figure below, His carries out generates| tetrahedral intermediate is stabilized by the by accepting a proton from the serine hydroxyl sidechain. This the carbonyl carbon of the sessile bond. The formed to Choose from: SN1, electrophilic attack, oxyanion hole, nucleophilic attack, alkoxide, hydrophobic pocket, hydrophilic pocket, general base catalysis, and genemal acid catalysis. His Asp (102) 57 CH2 H2C Ser 195 1 CH2 R' Substrate N-C polypeptide H.
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:In the figure below, His caries out
generates
tetrahedral intermediate is stabilized by the
by accepting a proton from the serine hydroxyl sidechain. This
the carbonyl carbon of the sessile bond. The formed
to
Choose from: SN1, electrophilic attack, oxyanion hole, nucleophilic attack, alkoxide, hydrophobic pocket, hydrophilic
pocket, general base catalysis, and general acid catalysis.
His
Asp
(102)
57
CH2
H2C
Ser
(195)
1
CH2
R'
Substrate
polypeptide
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