In the circles please assign (E) or (Z) configuration to the double bonds indicated with an arrow. In the boxes please assign the absolute configuration i.e. (R) or (S) to the stereogenic centers indicated with an arrow. In the triangle please provide an approximate value for the pKa of the protons indicated with an arrow. Meo HO O MeO Но НО
Electronic Effects
The effect of electrons that are located in the chemical bonds within the atoms of the molecule is termed an electronic effect. The electronic effect is also explained as the effect through which the reactivity of the compound in one portion is controlled by the electron repulsion or attraction producing in another portion of the molecule.
Drawing Resonance Forms
In organic chemistry, resonance may be a mental exercise that illustrates the delocalization of electrons inside molecules within the valence bond theory of octet bonding. It entails creating several Lewis structures that, when combined, reflect the molecule's entire electronic structure. One Lewis diagram cannot explain the bonding (lone pair, double bond, octet) elaborately. A hybrid describes a combination of possible resonance structures that represents the entire delocalization of electrons within the molecule.
Using Molecular Structure To Predict Equilibrium
Equilibrium does not always imply an equal presence of reactants and products. This signifies that the reaction reaches a point when reactant and product quantities remain constant as the rate of forward and backward reaction is the same. Molecular structures of various compounds can help in predicting equilibrium.
Stereochemistry and pKa, ivermectin is an antibacterial and antiparascitic
![antibacterial and antiparascitic natural product that is produced by fermentation cultures of the
bacteria Streptomyces avermectilis. It is an inexpensive and well-tolerated treatment for river
blindness in humans caused by the parasitic nematode Onchocerce volvulus. It is also an
excellent horse dewormer. There is no scientific evidence that is has any effect on SARS-COV2.
Please examine the chemical structure carefully and answer the questions that follow.
In the circles please assign (E) or (Z) configuration to the double bonds indicated with an arrow.
In the boxes please assign the absolute configuration i.e. (R) or (S) to the stereogenic centers
indicated with an arrow. In the triangle please provide an approximate value for the pKa of the
protons indicated with an arrow.
4
HO
5.
MeO
НО
HO 07
НО
MeO
3
HỌ
eaositpho](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F297f3ac9-0b45-4f0e-a4c7-c62f78084607%2F53e78f72-f16c-4d1b-9b61-16477cf06f80%2Fzaefu8_processed.jpeg&w=3840&q=75)
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