Answered: In DNA repair, how does the normal…

Science

Biology

In DNA repair, how does the normal allele of BRCA1 work? Is it an oncogene or a tumor suppressor gene?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter12: Genes And Cancer

Section: Chapter Questions

Problem 16QP

See similar textbooks

Related questions

Q: directly to DNA and plays a critical role in determining whether the DNA will be repaired or the…

A: p53 Mutations are a Frequent Event in Cancer:--The evolution in a normal cell producing cancerous…

Q: (b) How many forms can naturally occurring DNA exist in? Explain how these forms are characterized.…

A: DNA Deoxyribonucleic acid Genetic material in many species Has ds(double stranded) structure…

Q: Match the type of chromatin modification with the most likely effect on gene expression near the…

A: DNA and histone proteins, which are essential elements of the chromatin structure, are chemically…

Q: What role do tumor suppressors, including p53, play in mediating cell cycle arrest for cells with…

A: The cell cycle is an ordered series of events by which a cell duplicates its genome and divides into…

Q: What is the difference in an oncogene and tumor suppressor gene and how can each potentially lead to…

A: Cancer is group of diseases which are characterized by abnormal and unstoppable growth of cell and…

Q: According to the multi-hit model, more than one mutation must occur in a cell for cancer to develop.…

A: A new multihit model of carcinogenesis is produced for use in assessing age-explicit disease rate…

Q: Retinoblastoma is an extremely rare cancer of the retina in the eye. The disease mainly affects…

A: The investigation into retinoblastoma, a uncommon eye cancer fundamentally influencing children,…

Q: Hair loss is a well-known side effect of chemotherapy; why does this side effect occur? (1)…

A: Chemotherapy is a treatment that affects the whole body. This implies that it circulates throughout…

Q: X31b is an experimental compound that is taken up by rapidly dividing cells. Research has shown that…

A: Cancer is a disorder in which abnormal cells divide irrepressibly and destroy the tissues of body.…

Q: Which of the following effectively describes the situation of someone with an inherited…

A: Breast cancer is a condition in which abnormal cells in the breast grow uncontrolled, resulting in a…

Q: List the regulatory mechanisms that might be lost in a cell producing faulty p53.

A: The cell cycle is the series of events that lead to the formation of new cells from the parent…

Q: Which of the following types of mutations would be most likely to cause cells to undergo apoptosis…

A: p53 is a tumor suppressor protein that plays a crucial role in regulating the cell cycle and…

Q: How do BRCA1 and BRCA2 function in regard to cell proliferation (are they proto-oncogenes,…

A: jjBRCA proteins play an important role in a variety of biological functions. In response to DNA…

Q: The proteins work together to cause the release of the transcription factor that is bound by the…

A: Tumor suppressor genes are for controlling and stopping the growth of cancerous cells. They inhibit…

Q: what are the rolls that the p53 gene and RAS protein take on when trying to stop a cancer cell from…

A: Given: Role of p53 and RAS protein to stop a cancer cell from replication. What happens if mutation…

Q: As the most junior member of a lab, you are tasked with generating cell lines that accumulate DNA…

A: If DNA damage occurs then the cell cycle will be arrested and the cell try to repair the damaged…

Concept explainers

Viral Replication

The virus is acellular and considered non-living outside the host cell. The replication of the virus occurs only inside the living cells. Only a few genes are present in the smallest virus, whereas many genes are present in the largest virus. These genes encode specific viral proteins.

Question

In DNA repair, how does the normal allele of BRCA1 work? Is it an oncogene or a tumor suppressor gene?

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

This is a popular solution!

SEE SOLUTION Check out a sample Q&A here

Introduction

VIEW

Explanation

VIEW

Trending now

This is a popular solution!

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.

Similar questions

What is the difference between a proto-oncogene and a tumor-suppressor gene?
Why do mutations in genes that encode DNA-repair enzymes often produce a predisposition to cancer?
Why is p53 considered a tumor suppressor protein? Question 12 options: a) Because p53 normally detects breaks in DNA. b) Because p53 normally causes progression from G1 to S phase to halt until damaged DNA is fully repaired. c) Because p53 normally repairs breaks in DNA. d) Because p53 normally stimulates transcription of Repair Polymerase. e) Because p53 normally reduces the mutation rate of DNA polymerase.
Some cancers are consistently associated with the deletion of a particularpart of a chromosome. Does the deleted region contain an oncogene or atumor-suppressor gene? Explain.
A cell inherits a mutation in a gene that results in a transcription factor, called NF-kB, constantly being in its active conformation. When active, NF-kB stimulates the expression of cyclins that promote progression of the cell cycle, regardless of other conditions. As a result of this mutation, how would this cell's phenotype be affected by this mutation? A) This cell would have a cancer phenotype B) This cell would grow larger in size, but would never divide C) This cell would likely undergo apoptosis D) This cell would not duplicate its chromosomes .
The p53 pathway is important for regulating the cell cycle. In a normal cell, there is a protein called mdm2 that can bind to p53 and deactivate it. A diseased individual has amutation in the gene that codes for mdm2, resulting in an mdm2 protein that is less able to bind to p53. Will this mutation increase, decrease, or cause no change in the rate of cell death? Explain.
Why do mutations in DNA repair genes increase the likelihood of developing cancer?
How can mutations in noncoding segments of DNA contribute to the development of cancers?
How do we know that malignant tumors arise from a single cell that contains mutations?
Which of the following is an example of a proto-oncogene? 1) cell cycle inhibitor 2) tumor suppressor 3) oncogene 4) repair enzyme 5) growth factor receptor
Why don’t all loss-of-function mutations that are recessive at the cellular level behave as dominants at the organismal level? Is this property restricted to tumor-suppressor gene mutations?
Let’s suppose you were interested in developing drugs to preventepigenetic changes that may contribute to cancer. What cellularproteins would be the target of your drugs? What possible sideeffects might your drugs cause?