In an effort to explore the activity of steroid-cyclizing enzymes, Compound X below was used as a substrate for oxidosqualene cyclase. Interestingly, the enzyme accepted this unnatural substrate and yielded Compound Y as the product. OMe oxidosqualene cyclase OMe Compound X I HO Compound Y a) Provide a complete curved-arrow mechanism for this transformation. While you do not have to show carbocation intermediates in the cyclization cascade, you must show the most stable resonance structure for any intermediate carbocations that result from this cascade prior to quenching. You do not have to account for the observed stereochemistry.

In an effort to explore the activity of steroid-cyclizing enzymes, Compound X below was used as a substrate for oxidosqualene cyclase. Interestingly, the enzyme accepted this unnatural substrate and yielded Compound Y as the product. OMe oxidosqualene cyclase OMe Compound X I HO Compound Y a) Provide a complete curved-arrow mechanism for this transformation. While you do not have to show carbocation intermediates in the cyclization cascade, you must show the most stable resonance structure for any intermediate carbocations that result from this cascade prior to quenching. You do not have to account for the observed stereochemistry.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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