In 3-5 Sentences  Explain the difference between normal p53 and mutated p53.

Q: In a few sentences, describe how p53 guards the genome. Include at least two specific ways that p53…

A: The TP53 ( Tumor protein 53) also known as P53. This gene codes for cell cycle regulatory proteins…

Q: Name conditions caused by abnormalities of vertical linkages and horizontal (lateral) linkages in…

A: Deformation of the membrane: During RBC deformation, specttrin dimer linkages that emerge along the…

Q: Cancer cells generally have missense mutations in p53 gene, resulting in truncated p53 normally…

A: A normal cell is converted into a cancer cell when the there is deactivation of the tumor suppressor…

Q: 8 months old, showe an increase of the liver, a decrease in blood glucose, a decrease in the…

A: The type of cell damage seen in this disorder is is intracellular accumulation leading to cell…

Q: Describe the importance of Wee1, Myt1, CAK and cdc25 activity on the activation of the cyclin B/CDK1…

A: CDKs are the proteins whose concentration increases or decreases during the cell cycle. The…

Q: There is no change in the DNA sequence when stem cells differentiate into different cell types.…

A: Stem cells are the earliest type of the cell in cell lineage in multicellular organism. They are…

Q: One of your patients, a six-year-old girl who suffers from Sickle cell anemia, an inherited blood…

A: Sickle cell anemia is a rare genetic disorder that follows an autosomal recessive inheritance…

Q: Explain The p53 pathway is part of the G1-to-S checkpoint?

A: As with most body processes, the cell cycle is highly regulated to prevent mutated cell synthesis…

Q: Discuss about cytokinesis

A: Cytokinesis : It is the physical process of cell division which divides the cytoplasm of a parental…

Q: Mutations in the RB gene are often associated with cancer. Explain how a mutation that results in a…

A: The cell cycle is the series of stages that allow the cell to pass from one cell division to…

Q: T/F : Proto oncogenes and tumor suppressor genes may lead to cancer if mutated multiple times.

A: Proto-oncogenes are normal genes that can become oncogenes when they are mutated in specific ways. A…

Q: Describe the roles of proto-oncogenes and tumor suppressor genes in controlling cell growth, and…

A: Oncogenesis is the process of inducing cancer in the body due to mutation in the genes. Oncogenes…

Q: p53 is a gene / protein often associated with cancer.  Why?  What does p53 do?  What kind of gene is…

A: p53 is a tumor suppressor gene it is called so because its activity stops the formation of…

Q: "In the cellular regulatory pathways that control cell growth and proliferation, the products of…

A: Normal genes that are changed to become oncogenes are known as proto-oncogenes. They carry out a…

Q: What is the importance of determining the patient's onset of menses and the number of pregnancies?

A: MM is 54 year old female.  She is diagnosed with  intraductal adenocarcinoma of the left breast 5…

Q: Explain about the Cancer-causing gene formed by a mutation in a proto-oncogene ?

A: In genetics, the mutation is defined as the changes or alteration in the DNA sequences which result…

Q: For the normal cell to become a cancer cell, mutations should take place in protooncogenes to become…

A: Cancer cells divide incessantly, producing solid tumors or infiltrating the bloodstream with…

Q: Explain why mutations can give rise to neoplasms

A: The genetic alteration results in the advantage in growth of the cell. The 3 genetic change…

Q: Some studies have pointed that mutant p53 proteins have gained a novel function by inactivating…

A: P53 is an important protein that is considered a tumor-suppressing gene. The presence of p53…

Q: To explain the mechansim of histocompatibility.

A: Innate defence and adaptive defence are two bodily processes that guard against pathogens. Innate…

Q: Remember that DNA viruses inactivate tumor suppressor genes resulting in cancer. In Burkitt’s…

A: Translocation of c-myc occurs to one of the immunoglobulin foci. This leads to over expression of…

Q: Why is the p53-meditated apoptosis pathway, and the GSK3 signaling pathway important for cancer…

A: p53 is a critical tumour suppressor that is mutated in ~50% of human cancers. Inunstressed cells p53…

Q: // Which CDK and cyclin does p53 ultimately target in DNA damaged conditions? O CDK1/cyclin E O…

A: CDK phosphorylate soecific target proteins. They required cyclin to be activate. CDK-cyclin…

Q: 1-2 paragraphs  the role of stem cells

A: Introduction  Almost all types of cells have the ability to divide and produce daughter cells with…

Q: Mr. X, aged 85, was recently diagnosed with a particular type of brain tumor and was referred to Dr.…

A: To solve this problem, we will create a decision tree to visualize the decision-making process and…

Q: Describe the underlying causes of epigenetic changes associated with cancer.

A: DNA is the genetic material in most living organisms. It is the information hub of the cell that…

Q: Which of the following would most likely promote necrosis?

A: The death of cells or any tissue of body is called as necrosis. Whenever tissue is not getting…

Q: SCENARIO: MM, a 54-year old female presents to the Family Medicine Clinic due to a 2-week history…

A: Glyburide is used for treating diabetes mellitus type II by the mechanism of increasing the insulin…

Q: A second hit might arise because of viral infection. Tumor-initiating viruses often target RB1 for…

A: A virus is a microscopic infectious agent that can only replicate inside the living cells of…

Q: The P63 and P53 have similar functionalities in the cell, however, p53 is rarely associated directly…

A: Tumor protein 63 (p63) could also be a transcription factor of the p53 gene family encoded by the…

Q: Describe how a transgenic mouse is created and describe an experiment it could be used in.

A: As per our company guideline we are supposed to answer only 1st question or 1st 3 sub parts of the…

Q: Normal p53 is a tumor suppressor gene, when mutated it loses this function. Explain how a tissue…

A: Cancer usually develops when a mutation in a gene results in the formation of a faulty protein that…

Q: Describe the difference between a tumor suppressor and an oncogene with respect to the actual causes…

A: Cancer is caused due to the uncontrollable division of cells leading to tumor formation. Genetic…

Q: In adult cells that have stopped dividing, what types ofrepair systems are possible?

A: DNA repair mechanisms remove the errors from DNA and maintain the integrity of the genetic…

Q: What is the role of the cell cycle in cancer? Summarize around 3-5 sentences. Cite plz.

A: Step 1 Cancer is a disease characterised by breaking down of regulatory mechanism of normal cells,…

Q: Relatively few inherited forms of cancer involve the inheritance of mutant oncogenes. Instead, most…

A: Cancer is an uncontrolled division of cell that has a defunct apoptosis mechanism. Usually, when…

Q: SCENARIO: MM, a 54-year old female presents to the Family Medicine Clinic due to a 2-week history…

A: Introduction:-  Breast carcinoma is very common cancer in females and occurs most commonly in the…

Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.