Question 7Immuno-oncologists wanted to examine whether combination therapy with nivolumab and ipilimumab improved survival in melanoma patients compared to treatment with ipilimumabalone. They plan to first obtain approval from the institutional review board, identify melanoma patients, randomly assign some patients to combination therapy and others totreatment with ipilimumab alone, and follow these patients a certain period of time to record their survival.This study is an example of (Choose one from choices given):O None of the choices are correctO Experimental design (aka: interventional)O Non-Experimental design (aka: observationalO Survey design

Answered: Immuno-oncologists wanted to examine…

MATLAB: An Introduction with Applications

6th Edition

ISBN:9781119256830

Author:Amos Gilat

Publisher:Amos Gilat

Chapter1: Starting With Matlab

Section: Chapter Questions

Problem 1P

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Captivity can influence immunological responses in some mammals. Seeber et al. (2020) investigated various aspects of immunological responses in captive and free-ranging zebras. One aspect of the study involved samples of 12 free-ranging zebras from Namibia, 9 from Tanzania, and 38 captive zebras from various zoos in Europe. (All of these were non-lactating females.) One of the measured variables from blood samples was lysozyme concentration (μg/L). (Lysozyme is a biomarker of the immune response.) The researchers were interested in investigating possible differences in lysozyme concentration between zebras in the various locations. As part of the analysis, they carried out a one-way ANOVA on the lysozyme concentrations for the zebras from the 3 locations, and found the following output. Df Sum Sq Mean Sq F value Pr(>F) Location 2 50.65 25.33 42.24 6.54e-12Residuals 56 33.57 0.60 Suppose the assumptions of one-way ANOVA…
The Diabetes Control and Complications trial research group, randomly assigned volunteers with type 1 (insulin-dependent) diabetes mellitus, but without retinopathy, either to a conventional treatment or to a more intensive treatment aimed at maintaining normal blood glucose levels. The volunteers' health was monitored closely for approximately six years. By the end of the study, 91 patients out of 378 in the conventional treatment group had developed retinopathy, whereas 23 out of 348 in the intensive treatment group had developed retinopathy. Test whether the rates of retinopathy differed significantly between the two treatment groups, if they did, which rate was significantly lower. 1. Provide the null hypothesis 2. Provide the alternative hypotheses 3. calculate the appropriate test statistic. Show all work 4. Identify the p-value for that test statistic 5. Using the p-value method and an alpha level of 0.02 state what your conclusions are regarding the null hypothesis, and…
A researcher suspects that the actual prevalence of generalized anxiety among children and adolescents is higher than the previously reported prevalence of generalized anxiety disorder among children and adolescents. The previously reported prevalence of generalized anxiety disorder among children and adolescents is 4.1%, and the researcher conducts a study to test the accuracy of the previously reported prevalence of generalized anxiety disorder by recruiting 98 children and adolescents from various pediatricians’ offices and tests them for generalized anxiety disorder using the DSM-5. The researcher determines that the prevalence of generalized anxiety disorder among the participants of the study is 6.8%. For a level of significance of 5%, what should the researcher’s decision rule look like? Reject H0 if z is less than or equal to -1.96. Reject H0 if z is greater than or equal to 1.96. Reject H0 if z is less than or equal to -1.645. Reject H0 if z is greater than or equal to…
A researcher suspects that the actual prevalence of generalized anxiety among children and adolescents is higher than the previously reported prevalence of generalized anxiety disorder among children and adolescents. The previously reported prevalence of generalized anxiety disorder among children and adolescents is 3.9%, and the researcher conducts a study to test the accuracy of the previously reported prevalence of generalized anxiety disorder by recruiting 98 children and adolescents from various pediatricians’ offices and tests them for generalized anxiety disorder using the DSM-5. The researcher determines that the prevalence of generalized anxiety disorder among the participants of the study is 6.1%. The researcher’s hypothesis, for a level of significance of 5%, should resemble which of the following sets of hypothesis? A) H0: p > .039; H1: p = .039; alpha= .05 B) H0: p = .039; H1: p > .039; alpha= .05 C) H0: p > .039; H1: p = .039; alpha= .95 D) H0: p = .039; H1: p…
A pharmaceutical company has developed a new drug called Antisubcillin to treat substance use disorder. They have just completed an experiment assessing the safety of the drug. To test safety, 100 rats were given 20 mg of Antisubcillin and 100 rats were given a placebo. The study was conducted as a double-blind controlled study and so the researchers did not know which rats were receiving the drug and which were receiving the placebo. The number of negative side effects displayed by each rat over the course of 8 weeks was recorded. Which statistical test should be used to analyze these data? z test one-sample t test independent samples t test dependent samples t test
A2
More than 10% of people carry the parasite Toxoplasma gondii. The life-long presence of Toxoplasma cysts in neural and muscular tissues leads to prolongation of reaction times in infected subjects. The following table gives data from Prague on 15- to 29-year-old drivers who had been and had not been involved in accidents. The table also gives the number of drivers who were infected with Toxoplasma gondii and who were uninfected. Infected Uninfected Drivers with accidents 21 38 Drivers without accidents 38 211 Source: Flegr. J Havlicek, J., Kodym, P. Malý, M. & Smahel, Z. (2002). Increased risk of traffic accidents in subjects with latent toxoplasmosis: a retrospective case- control study. BMC infectious diseasex, 2, 11. https://doi.org/10.1186/1471-2334-2-11 Complete the sentences to form the correct statements identifying the explanatory and response variables. Select from here: infection status. The explanatory variable is place of living. accident state. The response variable is age…

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