If only the first five loci listed in Table 1 of the assigned paper (Forensics, DNA Fingerprinting, and CODIS) were analyzed, what would be the statistical probability of finding that particular genotype among people other than Suspect B? SHOW YOUR WORK! Hint: Multiply together the frequencies of the individual STR genotypes to obtain the overall profile frequency
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If only the first five loci listed in Table 1 of the assigned paper (
Hint: Multiply together the frequencies of the individual STR genotypes to obtain the overall profile frequency.
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- Achondroplasia is an autosomal dominant form of dwarfism caused by a single gene mutation. Calculate the mutation rate of this gene given the following data: 10 achondroplastic births to unaffected parents in 245,000 births.Can DNA profiling identify the source of a sample with absolute certainty? Because any two human genomes differ at about 3 million sites, no two persons (except identical twins) have the same DNA sequence. Unique identification with DNA profiling is therefore possible if enough sites of variation are examined. However, the systems used today examine only a few sites of variation. Nonetheless, even with todays technology, which uses three to five loci, a match between two DNA patterns can be considered strong evidence that the two samples came from the same source. DNA profiling in criminal cases has been a useful tool in establishing both guilt and innocence. Originally, DNA databases contained only the profiles of convicted felons. Over time, however, law enforcement agencies have expanded the collection and use of DNA profiles, and these new policies are causing controversies, once again illustrating how the availability and use of genetic technology is often ahead of consensus on how and when this technology should be used. One of these new policies is postarrest DNA collection. At this writing, 18 U.S. states as well as the federal government allow the collection of DNA samples after an arrest but before conviction. These profiles become part of the states DNA database, which is often searched for evidence in cold cases. Courts across the country have ruled for and against the use of such samples. In 2012, the Maryland Court of Appeals ruled that the collection of DNA samples from someone who has been arrested but not convicted is unconstitutional and violates an individuals right to be free from unreasonable search and seizure. The case began when a DNA sample was taken from Alonzo Jay King, Jr., who was arrested in 2009 for assault. In a database search, the DNA profile matched that taken from a 2003 unsolved rape. Based on the results of the database search, the man was sentenced to life in prison. The rape conviction was reversed, and the case was sent back to a lower court. As a result, some 16,000 DNA profiles collected postarrest but preconviction since 2009 cannot be used pending appeal of this decision. Before the court decision, postarrest DNA profiles were used in 65 arrests that resulted in 34 convictions, with an additional 12 cases pending. Supporters of postarrest DNA profiling claim that taking a DNA sample by a cheek swab is noninvasive and no different from taking someones fingerprints. Opponents claim that because DNA samples can be used to determine much more than a DNA profile, they are a threat to privacy, and that because minorities are more likely to be arrested, the practice is discriminatory. What are your thoughts on the collection and use of postarrest DNA profiles?Can DNA profiling identify the source of a sample with absolute certainty? Because any two human genomes differ at about 3 million sites, no two persons (except identical twins) have the same DNA sequence. Unique identification with DNA profiling is therefore possible if enough sites of variation are examined. However, the systems used today examine only a few sites of variation. Nonetheless, even with todays technology, which uses three to five loci, a match between two DNA patterns can be considered strong evidence that the two samples came from the same source. DNA profiling in criminal cases has been a useful tool in establishing both guilt and innocence. Originally, DNA databases contained only the profiles of convicted felons. Over time, however, law enforcement agencies have expanded the collection and use of DNA profiles, and these new policies are causing controversies, once again illustrating how the availability and use of genetic technology is often ahead of consensus on how and when this technology should be used. One of these new policies is postarrest DNA collection. At this writing, 18 U.S. states as well as the federal government allow the collection of DNA samples after an arrest but before conviction. These profiles become part of the states DNA database, which is often searched for evidence in cold cases. Courts across the country have ruled for and against the use of such samples. In 2012, the Maryland Court of Appeals ruled that the collection of DNA samples from someone who has been arrested but not convicted is unconstitutional and violates an individuals right to be free from unreasonable search and seizure. The case began when a DNA sample was taken from Alonzo Jay King, Jr., who was arrested in 2009 for assault. In a database search, the DNA profile matched that taken from a 2003 unsolved rape. Based on the results of the database search, the man was sentenced to life in prison. The rape conviction was reversed, and the case was sent back to a lower court. As a result, some 16,000 DNA profiles collected postarrest but preconviction since 2009 cannot be used pending appeal of this decision. Before the court decision, postarrest DNA profiles were used in 65 arrests that resulted in 34 convictions, with an additional 12 cases pending. Supporters of postarrest DNA profiling claim that taking a DNA sample by a cheek swab is noninvasive and no different from taking someones fingerprints. Opponents claim that because DNA samples can be used to determine much more than a DNA profile, they are a threat to privacy, and that because minorities are more likely to be arrested, the practice is discriminatory. Would you object if you were arrested for a minor offense, such as a traffic violation, and ordered to provide a DNA sample?
- Can DNA profiling identify the source of a sample with absolute certainty? Because any two human genomes differ at about 3 million sites, no two persons (except identical twins) have the same DNA sequence. Unique identification with DNA profiling is therefore possible if enough sites of variation are examined. However, the systems used today examine only a few sites of variation. Nonetheless, even with todays technology, which uses three to five loci, a match between two DNA patterns can be considered strong evidence that the two samples came from the same source. DNA profiling in criminal cases has been a useful tool in establishing both guilt and innocence. Originally, DNA databases contained only the profiles of convicted felons. Over time, however, law enforcement agencies have expanded the collection and use of DNA profiles, and these new policies are causing controversies, once again illustrating how the availability and use of genetic technology is often ahead of consensus on how and when this technology should be used. One of these new policies is postarrest DNA collection. At this writing, 18 U.S. states as well as the federal government allow the collection of DNA samples after an arrest but before conviction. These profiles become part of the states DNA database, which is often searched for evidence in cold cases. Courts across the country have ruled for and against the use of such samples. In 2012, the Maryland Court of Appeals ruled that the collection of DNA samples from someone who has been arrested but not convicted is unconstitutional and violates an individuals right to be free from unreasonable search and seizure. The case began when a DNA sample was taken from Alonzo Jay King, Jr., who was arrested in 2009 for assault. In a database search, the DNA profile matched that taken from a 2003 unsolved rape. Based on the results of the database search, the man was sentenced to life in prison. The rape conviction was reversed, and the case was sent back to a lower court. As a result, some 16,000 DNA profiles collected postarrest but preconviction since 2009 cannot be used pending appeal of this decision. Before the court decision, postarrest DNA profiles were used in 65 arrests that resulted in 34 convictions, with an additional 12 cases pending. Supporters of postarrest DNA profiling claim that taking a DNA sample by a cheek swab is noninvasive and no different from taking someones fingerprints. Opponents claim that because DNA samples can be used to determine much more than a DNA profile, they are a threat to privacy, and that because minorities are more likely to be arrested, the practice is discriminatory. What if you learned that law enforcement officials were saving the DNA sample for use in tests that might be developed in the future?Use the following information to respond to the three questions posed below: (1) The proband (affected individual who led to the construction of the pedigree) exhibits the trait. (2) Neither her husband nor her only sibling, an older brother, exhibits the trait. (3) The proband has five children by her current husband. The oldest is a boy, followed by a girl, then another boy, and then identical twin girls. Only the second oldest fails to exhibit the trait. (4) Both parents of the proband show the trait. a. Construct a pedigree of the trait in this family. b. Determine how the trait is inherited (go step by step to examine each possible pattern of inheritance). c. Can you deduce the genotype of the probands husband for this trait?Figure 13.4 Which of the following statements is true? Recombination of the body color and red/ cinnabar eye alleles will occur more frequently than recombination of the alleles for wing length and aristae length. Recombination of the body color and aristae length alleles will occur more frequently than recombination of red/brown eye alleles and the aristae length alleles. Recombination of the gray/black body color and long/short aristae alleles will not occur. Recombination of the red/brown eye and long/short aristae alleles will occur more frequently than recombination of the alleles for wing length and body color.
- A single allele gives rise to the Hbs form of hemoglobin. Individuals who are homozygous for the allele (HbS/HbS) develop sickle-cell anemia (Section 9.6). Heterozygous individuals (HbA/HbS) have few symptoms. A couple who are both heterozygous for the HbS allele plan to have children. For each of the pregnancies, state the probability that they will have a child who is: a. homozygous for the HbS allele b. homozygous for the normal allele (HbA) c. heterozygous: HbA/HbSIdentify a possible advantage and a possible disadvantage of a genetic test that would identify genes in individuals that increase their probability of having Alzheimer’s disease later in life.If the genotype frequencies in a population are 0.60 AA, 0.20 Aa, and 0.20 aa, and if the requirements of the HardyWeinberg principle apply, the genotype frequencies in the offspring generation will be: a. 0.60 AA, 0.20 Aa, 0.20 aa. b. 0.36 AA, 0.60 Aa, 0.04 aa. c. 0.49 AA, 0.42 Aa, 0.09 aa. d. 0.70 AA, 0.00 Aa, 0.30 aa. e. 0.64 AA, 0.32 Aa, 0.04 aa.
- A couple was referred for genetic counseling because they wanted to know the chances of having a child with dwarfism. Both the man and the woman had achondroplasia (MIM 100800), the most common form of short-limbed dwarfism. The couple knew that this condition is inherited as an autosomal dominant trait, but they were unsure what kind of physical manifestations a child would have if it inherited both mutant alleles. They were each heterozygous for the FGFR3 (MIM 134934) allele that causes achondroplasia. Normally, the protein encoded by this gene interacts with growth factors outside the cell and receives signals that control growth and development. In achrodroplasia, a mutation alters the activity of the receptor, resulting in a characteristic form of dwarfism. Because both the normal and mutant forms of the FGFR3 protein act before birth, no treatment for achrondroplasia is available. The parents each carry one normal allele and one mutant allele of FGRF3, and they wanted information on their chances of having a homozygous child. The counsellor briefly reviewed the phenotypic features of individuals with achondroplasia. These include facial features (large head with prominent forehead; small, flat nasal bridge; and prominent jaw), very short stature, and shortening of the arms and legs. Physical examination and skeletal X-ray films are used to diagnose this condition. Final adult height is approximately 4 feet. Because achondroplasia is an autosomal dominant condition, a heterozygote has a 1-in-2, or 50%, chance of passing this trait to his or her offspring. However, about 75% of those with achondroplasia have parents of average size who do not carry the mutant allele. In these cases, achondroplasia is due to a new mutation. In the couple being counseled, each individual is heterozygous, and they are at risk for having a homozygous child with two copies of the mutated gene. Infants with homozygous achondroplasia are either stillborn or die shortly after birth. The counselor recommended prenatal diagnosis via ultrasounds at various stages of development. In addition, a DNA test is available to detect the homozygous condition prenatally. What is the chance that this couple will have a child with two copies of the dominant mutant gene? What is the chance that the child will have normal height?A couple was referred for genetic counseling because they wanted to know the chances of having a child with dwarfism. Both the man and the woman had achondroplasia (MIM 100800), the most common form of short-limbed dwarfism. The couple knew that this condition is inherited as an autosomal dominant trait, but they were unsure what kind of physical manifestations a child would have if it inherited both mutant alleles. They were each heterozygous for the FGFR3 (MIM 134934) allele that causes achondroplasia. Normally, the protein encoded by this gene interacts with growth factors outside the cell and receives signals that control growth and development. In achrodroplasia, a mutation alters the activity of the receptor, resulting in a characteristic form of dwarfism. Because both the normal and mutant forms of the FGFR3 protein act before birth, no treatment for achrondroplasia is available. The parents each carry one normal allele and one mutant allele of FGRF3, and they wanted information on their chances of having a homozygous child. The counsellor briefly reviewed the phenotypic features of individuals with achondroplasia. These include facial features (large head with prominent forehead; small, flat nasal bridge; and prominent jaw), very short stature, and shortening of the arms and legs. Physical examination and skeletal X-ray films are used to diagnose this condition. Final adult height is approximately 4 feet. Because achondroplasia is an autosomal dominant condition, a heterozygote has a 1-in-2, or 50%, chance of passing this trait to his or her offspring. However, about 75% of those with achondroplasia have parents of average size who do not carry the mutant allele. In these cases, achondroplasia is due to a new mutation. In the couple being counseled, each individual is heterozygous, and they are at risk for having a homozygous child with two copies of the mutated gene. Infants with homozygous achondroplasia are either stillborn or die shortly after birth. The counselor recommended prenatal diagnosis via ultrasounds at various stages of development. In addition, a DNA test is available to detect the homozygous condition prenatally. Should the parents be concerned about the heterozygous condition as well as the homozygous mutant condition?A couple was referred for genetic counseling because they wanted to know the chances of having a child with dwarfism. Both the man and the woman had achondroplasia (MIM 100800), the most common form of short-limbed dwarfism. The couple knew that this condition is inherited as an autosomal dominant trait, but they were unsure what kind of physical manifestations a child would have if it inherited both mutant alleles. They were each heterozygous for the FGFR3 (MIM 134934) allele that causes achondroplasia. Normally, the protein encoded by this gene interacts with growth factors outside the cell and receives signals that control growth and development. In achrodroplasia, a mutation alters the activity of the receptor, resulting in a characteristic form of dwarfism. Because both the normal and mutant forms of the FGFR3 protein act before birth, no treatment for achrondroplasia is available. The parents each carry one normal allele and one mutant allele of FGRF3, and they wanted information on their chances of having a homozygous child. The counsellor briefly reviewed the phenotypic features of individuals with achondroplasia. These include facial features (large head with prominent forehead; small, flat nasal bridge; and prominent jaw), very short stature, and shortening of the arms and legs. Physical examination and skeletal X-ray films are used to diagnose this condition. Final adult height is approximately 4 feet. Because achondroplasia is an autosomal dominant condition, a heterozygote has a 1-in-2, or 50%, chance of passing this trait to his or her offspring. However, about 75% of those with achondroplasia have parents of average size who do not carry the mutant allele. In these cases, achondroplasia is due to a new mutation. In the couple being counseled, each individual is heterozygous, and they are at risk for having a homozygous child with two copies of the mutated gene. Infants with homozygous achondroplasia are either stillborn or die shortly after birth. The counselor recommended prenatal diagnosis via ultrasounds at various stages of development. In addition, a DNA test is available to detect the homozygous condition prenatally. What if the couple wanted prenatal testing so that a normal fetus could be aborted?