Hepatocellular carcinoma (HCC) is among theleading causes of cancer death worldwide. Studies of geneexpression in HCC cells demonstrated that the enzyme ornithineaminotransferase (OAT) is upregulated in these cells. Ornithine(structure to the right) is both an intermediate in the urea cycleas well as a precursor for the synthesis of the nonessentialamino acid proline. Unlike many aminotransferases, OAT actson the side chain amine of ornithine rather than the alpha-amino3.group.If OAT takes ornithine and alpha-ketoglutarate as(a)substrates, draw the structures of the products released aftercatalysis.(b)What cofactor does OAT use and how is it linked to the enzyme?Devise a strategy to alleviate HCC based on OAT and describe the specific steps required(c)to accomplish this. What is a major challenge in this approach? What pre-clinical effects would youwant to demonstrate before attempting to treat patients?

Aminotransferases are group of enzymes that catalyzes the transamination reaction between amino acid…

Answered: If OAT takes ornithine and…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

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Problem 1P

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If OAT takes ornithine and alpha-ketoglutarate as (a) substrates, draw the structures of the products released after catalysis.