Homework Help is Here – Start Your Trial Now!
Science
Biochemistry
If OAT takes ornithine and alpha-ketoglutarate as (a) substrates, draw the structures of the products released after catalysis.

If OAT takes ornithine and alpha-ketoglutarate as (a) substrates, draw the structures of the products released after catalysis.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
See similar textbooks
icon
Related questions
Question
Hepatocellular carcinoma (HCC) is among the leading causes of cancer death worldwide. Studies of gene expression in HCC cells demonstrated that the enzyme ornithine aminotransferase (OAT) is upregulated in these cells. Ornithine (structure to the right) is both an intermediate in the urea cycle as well as a precursor for the synthesis of the nonessential amino acid proline. Unlike many aminotransferases, OAT acts on the side chain amine of ornithine rather than the alpha-amino 3. group. If OAT takes ornithine and alpha-ketoglutarate as (a) substrates, draw the structures of the products released after catalysis. (b) What cofactor does OAT use and how is it linked to the enzyme? Devise a strategy to alleviate HCC based on OAT and describe the specific steps required (c) to accomplish this. What is a major challenge in this approach? What pre-clinical effects would you want to demonstrate before attempting to treat patients?
Transcribed Image Text:Hepatocellular carcinoma (HCC) is among the leading causes of cancer death worldwide. Studies of gene expression in HCC cells demonstrated that the enzyme ornithine aminotransferase (OAT) is upregulated in these cells. Ornithine (structure to the right) is both an intermediate in the urea cycle as well as a precursor for the synthesis of the nonessential amino acid proline. Unlike many aminotransferases, OAT acts on the side chain amine of ornithine rather than the alpha-amino 3. group. If OAT takes ornithine and alpha-ketoglutarate as (a) substrates, draw the structures of the products released after catalysis. (b) What cofactor does OAT use and how is it linked to the enzyme? Devise a strategy to alleviate HCC based on OAT and describe the specific steps required (c) to accomplish this. What is a major challenge in this approach? What pre-clinical effects would you want to demonstrate before attempting to treat patients?
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps with 2 images

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON
SEE MORE TEXTBOOKS