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If I put 10 mM ACh in the external solution instead of 2 mM, which of the following wo happen? O The channel would be open for more of the time O The ACh channel would pass more current when it is open none of the other choices are correct.

If I put 10 mM ACh in the external solution instead of 2 mM, which of the following wo happen? O The channel would be open for more of the time O The ACh channel would pass more current when it is open none of the other choices are correct.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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### Patch Clamp Measurement of Single ACh Receptor Current #### Diagram Description: - **Label (A):** The image shows a microelectrode technique used to measure the ionic currents passing through individual ion channels, specifically acetylcholine (ACh) receptors. - **Microcomponents:** - **Micropipette:** Used to isolate a small patch of membrane. - **Outside-out Membrane Patch:** Formed by the micropipette pulling away a portion of the membrane, leaving the exterior of the cell membrane exposed. - **ACh Receptor:** A protein that responds to the neurotransmitter acetylcholine. - **ACh (Acetylcholine) Molecules:** Shown binding to the receptor. - **Na+ (Sodium Ions):** Represent the flow of ions through the open channel. #### Graph Explanation: - **Title:** 2 mM Acetylcholine (ACh) - **Axes:** - **Y-Axis (I in pA):** Denotes the current in picoamperes. - **X-Axis (Time in ms):** Represents time in milliseconds. - **Channel State:** The graph shows fluctuation between two states: - **Channel Closed (0 pA):** Indicates periods when no current flows due to closed receptor channels. - **Channel Open (2 pA):** Indicates times when the ACh receptor channel opens, allowing current to pass. #### Question: **If I put 10 mM ACh in the external solution instead of 2 mM, which of the following would happen?** ##### Options: - The channel would be open for more of the time - The ACh channel would pass more current when it is open - None of the other choices are correct - The channel would inactivate This information provides insight into how changing the concentration of acetylcholine affects the opening and ion passage through receptor channels.
Transcribed Image Text:### Patch Clamp Measurement of Single ACh Receptor Current #### Diagram Description: - **Label (A):** The image shows a microelectrode technique used to measure the ionic currents passing through individual ion channels, specifically acetylcholine (ACh) receptors. - **Microcomponents:** - **Micropipette:** Used to isolate a small patch of membrane. - **Outside-out Membrane Patch:** Formed by the micropipette pulling away a portion of the membrane, leaving the exterior of the cell membrane exposed. - **ACh Receptor:** A protein that responds to the neurotransmitter acetylcholine. - **ACh (Acetylcholine) Molecules:** Shown binding to the receptor. - **Na+ (Sodium Ions):** Represent the flow of ions through the open channel. #### Graph Explanation: - **Title:** 2 mM Acetylcholine (ACh) - **Axes:** - **Y-Axis (I in pA):** Denotes the current in picoamperes. - **X-Axis (Time in ms):** Represents time in milliseconds. - **Channel State:** The graph shows fluctuation between two states: - **Channel Closed (0 pA):** Indicates periods when no current flows due to closed receptor channels. - **Channel Open (2 pA):** Indicates times when the ACh receptor channel opens, allowing current to pass. #### Question: **If I put 10 mM ACh in the external solution instead of 2 mM, which of the following would happen?** ##### Options: - The channel would be open for more of the time - The ACh channel would pass more current when it is open - None of the other choices are correct - The channel would inactivate This information provides insight into how changing the concentration of acetylcholine affects the opening and ion passage through receptor channels.
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