Identify the electrophilic centre that is attacked on the structure of parecoxib. For this question you will need to draw your answer on a separate sheet.

Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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b) The enzyme catalysed conversion of parecoxib to valdecoxib in the liver occurs via attack of a
nucleophile on parecoxib.
i.
ii.
Identify the electrophilic centre that is attacked on the structure of parecoxib. For this question
you will need to draw your answer on a separate sheet.
Describe a possible way in which the electrophilic centre could be further activated within the
active site of the enzyme. Use resonance structures to illustrate your answer. For this question
you will need to draw your answer on a separate sheet.
Transcribed Image Text:b) The enzyme catalysed conversion of parecoxib to valdecoxib in the liver occurs via attack of a nucleophile on parecoxib. i. ii. Identify the electrophilic centre that is attacked on the structure of parecoxib. For this question you will need to draw your answer on a separate sheet. Describe a possible way in which the electrophilic centre could be further activated within the active site of the enzyme. Use resonance structures to illustrate your answer. For this question you will need to draw your answer on a separate sheet.
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