Identical reactions are catalyzed by the enzyme hexokinase with a Km of 0.2 mM in le cells and by the enzyme glucokinase in the liver with a Km of ~5 mM (see reaction v). Glucose + ATP → Glucose 6-phosphate + ADP g the Michaelis-Menten curve below, indicate which line shows the progression of the ion catalyzed by hexokinase and which line shows the progression of the reaction rzed by glucokinase? When blood glucose levels are at 5mM which of the two enzymes e working at full capacity? The activity for which of these two enzymes will be responsive anges in substrate availability within the normal blood glucose range (4 - 10 mM)? normal fasting [glucose] org 5 7.5 10 12.5 2.5 blood glucose (mM) What is the Lineweaver-Burk plot and why is it often used for determining Vmax and Km?
Enzyme kinetics
In biochemistry, enzymes are proteins that act as biological catalysts. Catalysis is the addition of a catalyst to a chemical reaction to speed up the pace of the reaction. Catalysis can be categorized as either homogeneous or heterogeneous, depending on whether the catalysts are distributed in the same phase as that of the reactants. Enzymes are an essential part of the cell because, without them, many organic processes would slow down and thus will affect the processes that are important for cell survival and sustenance.
Regulation of Enzymes
A substance that acts as a catalyst to regulate the reaction rate in the living organism's metabolic pathways without itself getting altered is an enzyme. Most of the biological reactions and metabolic pathways in the living systems are carried out by enzymes. They are specific for their works and work in particular conditions. It maintains the best possible rate of reaction in the most stable state. The enzymes have distinct properties as they can proceed with the reaction in any direction, their particular binding sites, pH specificity, temperature specificity required in very few amounts.
![Q18: Identical reactions are catalyzed by the enzyme hexokinase with a Km of 0.2 mM in
muscle cells and by the enzyme glucokinase in the liver with a Km of ~5 mM (see reaction
below).
Glucose + ATP → Glucose 6-phosphate + ADP
Using the Michaelis-Menten curve below, indicate which line shows the progression of the
reaction catalyzed by hexokinase and which line shows the progression of the reaction
catalyzed by glucokinase? When blood glucose levels are at 5mM which of the two enzymes
will be working at full capacity? The activity for which of these two enzymes will be responsive
to changes in substrate availability within the normal blood glucose range (4 - 10 mM)?
100%
normal fasting
[glucose]
drg
7.5
10
2.5
blood glucose (mM)
Q19: What is the Lineweaver-Burk plot and why is it often used for determining Vmax and Km?
Relative Velocity (%)](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F4f9c5faa-1e54-4dbe-8532-7f5348c7cfbf%2F6b9e1b22-7637-47d7-a0e1-b0c9b9a3343b%2F4k49d3_processed.png&w=3840&q=75)
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