i. Identify the oxidation sate of both metal ions. ii. Explain the role of complex charge toward their bio-distribution properties. iii. Contrast their ligand coordination environments with respect to complex stability in vivo. iv. Using the structure of Ceretec only, predict the possible pharmacokinetic effects of substituting the peripheral methyl group (shown in red) with the following R groups; acetic (-CH₂COOH), isopropyl (-CH(CH3)2), and benzyl (-CH2C6H5).
i. Identify the oxidation sate of both metal ions. ii. Explain the role of complex charge toward their bio-distribution properties. iii. Contrast their ligand coordination environments with respect to complex stability in vivo. iv. Using the structure of Ceretec only, predict the possible pharmacokinetic effects of substituting the peripheral methyl group (shown in red) with the following R groups; acetic (-CH₂COOH), isopropyl (-CH(CH3)2), and benzyl (-CH2C6H5).
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:i. Identify the oxidation sate of both metal ions.
ii. Explain the role of complex charge toward their bio-distribution properties.
iii. Contrast their ligand coordination environments with respect to complex stability in
vivo.
iv. Using the structure of Ceretec only, predict the possible pharmacokinetic effects of
substituting the peripheral methyl group (shown in red) with the following R groups;
acetic (-CH₂COOH), isopropyl (-CH(CH3)2), and benzyl
(-CH2C6H5).
7+
•N:C......
oti
ZEO
•N:C
Tc
EN ya
•GEN
Cardiolite
H
H3C'''
H3C
H3C CH3
N
Ceretec
CH3
CH3
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VIEWStep 2: Oxidation States of Tc in cardiolite and Ceretec
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VIEWStep 5: IV. Pharmacokinetic Effects of Substituting Methyl Group in Ceretec:
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