Huntington disease is a neurodegenerative disease that appears in affected people late in life. It is a dominant trait controlled by a single gene and the dominant Huntington allele is rare. Suppose that Joe is diagnosed with Huntington disease. He is surprised because both of his parents are over 70 years old but do not have the disease. He talks to his parents about this and finds out that there is no history of Huntington disease on his father’s side, but his maternal grandfather and one of his mother’s aunts, who had both died before he was born, had suffered from Huntington disease. a. Does this story represent variable expressivity, or incomplete penetrance? b. Deduce, as much as you can, the genotypes of Joe, his mother, his father, and his maternal grandfather .

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
icon
Related questions
Question

Please answer fast

1. Huntington disease is a neurodegenerative disease that appears in affected people late in life. It is a dominant trait controlled by a single gene and the dominant Huntington allele is rare. Suppose that Joe is diagnosed with Huntington disease. He is surprised because both of his parents are over 70 years old but do not have the disease. He talks to his parents about this and finds out that there is no history of Huntington disease on his father’s side, but his maternal grandfather and one of his mother’s aunts, who had both died before he was born, had suffered from Huntington disease.

a. Does this story represent variable expressivity, or incomplete penetrance?

b. Deduce, as much as you can, the genotypes of Joe, his mother, his father, and his maternal grandfather .

Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

Blurred answer
Knowledge Booster
Respiratory infections
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education