H,SO, + CH3CHO NH2 NH ČH3

Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Chapter1: Chemical Foundations
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What's the mechanism? 

### Transcription and Explanation of Chemical Reaction

**Chemical Reaction:**

\[ \text{Reactant 1:} \]

- Structure: An aromatic ring with an iodine (I) substituent and a side chain consisting of an amine group (NH₂) attached to a two-carbon chain.
- Description: This is a meta-substituted iodo-benzylamine.

\[ \text{Plus (+)} \]

\[ \text{Reactant 2:} \]

- Formula: CH₃CHO
- Description: Acetaldehyde, an organic compound with the formula CH₃CHO.

**Reaction Conditions:**

- Reagent: H₂SO₄
- Role: Sulfuric acid (H₂SO₄) acts as a catalyst for the reaction.

**Reaction Outcome:**

\[ \text{Product:} \]

- Structure: A bicyclic compound with iodine (I) attached to the aromatic ring, a methyl (CH₃) group, and a nitrogen atom bonded within a newly formed heterocyclic amine structure.
- Description: The product is a bicyclic aromatic compound featuring an indole structure.

### Explanation:

The image illustrates a chemical reaction in which a benzylamine derivative reacts with acetaldehyde in the presence of sulfuric acid to form a bicyclic amine. Sulfuric acid serves as a catalyst, promoting the cyclization and formation of the indole product. This type of reaction is common in organic synthesis for constructing complex bicyclic structures.

The diagram helps visualize the transformation from simple reactants to a more complex fused ring system, indicating how substituents like iodine and methyl groups are positioned in the product.
Transcribed Image Text:### Transcription and Explanation of Chemical Reaction **Chemical Reaction:** \[ \text{Reactant 1:} \] - Structure: An aromatic ring with an iodine (I) substituent and a side chain consisting of an amine group (NH₂) attached to a two-carbon chain. - Description: This is a meta-substituted iodo-benzylamine. \[ \text{Plus (+)} \] \[ \text{Reactant 2:} \] - Formula: CH₃CHO - Description: Acetaldehyde, an organic compound with the formula CH₃CHO. **Reaction Conditions:** - Reagent: H₂SO₄ - Role: Sulfuric acid (H₂SO₄) acts as a catalyst for the reaction. **Reaction Outcome:** \[ \text{Product:} \] - Structure: A bicyclic compound with iodine (I) attached to the aromatic ring, a methyl (CH₃) group, and a nitrogen atom bonded within a newly formed heterocyclic amine structure. - Description: The product is a bicyclic aromatic compound featuring an indole structure. ### Explanation: The image illustrates a chemical reaction in which a benzylamine derivative reacts with acetaldehyde in the presence of sulfuric acid to form a bicyclic amine. Sulfuric acid serves as a catalyst, promoting the cyclization and formation of the indole product. This type of reaction is common in organic synthesis for constructing complex bicyclic structures. The diagram helps visualize the transformation from simple reactants to a more complex fused ring system, indicating how substituents like iodine and methyl groups are positioned in the product.
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