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How does the serum cholesterol level control both cholesterol synthesis in the liver and LDL uptake? When serum cholesterol concentration is low, the synthesis of cholesterol in the liver is inhibited, and the synthesis of cell receptors is increased. Serum cholesterol level controls the formation of cholesterol in the liver by regulating proteins that synthesize cholesterol. When serum cholesterol concentration is high, the synthesis of cholesterol in the liver is inhibited, and the synthesis of cell receptors is increased. Serum cholesterol level controls the formation of cholesterol in the liver by regulating enzymes that synthesize cholesterol. When serum cholesterol concentration is high, the synthesis of cholesterol in the liver is inhibited, and the synthesis of cell receptors is decreased. Serum cholesterol level controls the formation of cholesterol in the liver by regulating proteins that synthesize cholesterol. When serum cholesterol concentration is high, the synthesis of cholesterol in the liver is inhibited, and the synthesis of cell receptors is decreased. Serum cholesterol level controls the formation of cholesterol in the liver by regulating enzymes that synthesize cholesterol.

How does the serum cholesterol level control both cholesterol synthesis in the liver and LDL uptake? When serum cholesterol concentration is low, the synthesis of cholesterol in the liver is inhibited, and the synthesis of cell receptors is increased. Serum cholesterol level controls the formation of cholesterol in the liver by regulating proteins that synthesize cholesterol. When serum cholesterol concentration is high, the synthesis of cholesterol in the liver is inhibited, and the synthesis of cell receptors is increased. Serum cholesterol level controls the formation of cholesterol in the liver by regulating enzymes that synthesize cholesterol. When serum cholesterol concentration is high, the synthesis of cholesterol in the liver is inhibited, and the synthesis of cell receptors is decreased. Serum cholesterol level controls the formation of cholesterol in the liver by regulating proteins that synthesize cholesterol. When serum cholesterol concentration is high, the synthesis of cholesterol in the liver is inhibited, and the synthesis of cell receptors is decreased. Serum cholesterol level controls the formation of cholesterol in the liver by regulating enzymes that synthesize cholesterol.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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### Understanding Serum Cholesterol Levels and Their Control on Cholesterol Synthesis and LDL Uptake **Question: How does the serum cholesterol level control both cholesterol synthesis in the liver and LDL uptake?** **Options:** 1. When serum cholesterol concentration is low, the synthesis of cholesterol in the liver is inhibited, and the synthesis of cell receptors is increased. Serum cholesterol level controls the formation of cholesterol in the liver by regulating proteins that synthesize cholesterol. 2. When serum cholesterol concentration is high, the synthesis of cholesterol in the liver is inhibited, and the synthesis of cell receptors is increased. Serum cholesterol level controls the formation of cholesterol in the liver by regulating enzymes that synthesize cholesterol. 3. When serum cholesterol concentration is high, the synthesis of cholesterol in the liver is inhibited, and the synthesis of cell receptors is decreased. Serum cholesterol level controls the formation of cholesterol in the liver by regulating proteins that synthesize cholesterol. 4. When serum cholesterol concentration is high, the synthesis of cholesterol in the liver is inhibited, and the synthesis of cell receptors is decreased. Serum cholesterol level controls the formation of cholesterol in the liver by regulating enzymes that synthesize cholesterol. ### Explanation of Key Concepts - **Serum Cholesterol Concentration**: The amount of cholesterol present in the bloodstream. - **Cholesterol Synthesis in the Liver**: The process by which the liver produces cholesterol. - **Synthesis of Cell Receptors**: The production of cellular receptors, such as LDL receptors, which are involved in the uptake of cholesterol. ### Detailed Analysis #### Option Analysis: **Option 1:** Suggests that low serum cholesterol concentration inhibits cholesterol synthesis in the liver and increases receptor synthesis, with regulation through cholesterol-synthesizing proteins. **Option 2:** Suggests that high serum cholesterol concentration inhibits cholesterol synthesis in the liver and increases receptor synthesis, regulated by cholesterol-synthesizing enzymes. **Option 3:** Suggests that high serum cholesterol concentration inhibits cholesterol synthesis in the liver and decreases receptor synthesis, regulated by cholesterol-synthesizing proteins. **Option 4:** Suggests that high serum cholesterol concentration inhibits cholesterol synthesis in the liver and decreases receptor synthesis, regulated by cholesterol-synthesizing enzymes. #### Correct Answer: The correct answer is **Option 4:** - When serum cholesterol concentration is high, the synthesis of cholesterol in the liver is inhibited, and the synthesis of cell receptors is decreased. Serum cholesterol level controls the formation of cholesterol in the liver by
Transcribed Image Text:### Understanding Serum Cholesterol Levels and Their Control on Cholesterol Synthesis and LDL Uptake **Question: How does the serum cholesterol level control both cholesterol synthesis in the liver and LDL uptake?** **Options:** 1. When serum cholesterol concentration is low, the synthesis of cholesterol in the liver is inhibited, and the synthesis of cell receptors is increased. Serum cholesterol level controls the formation of cholesterol in the liver by regulating proteins that synthesize cholesterol. 2. When serum cholesterol concentration is high, the synthesis of cholesterol in the liver is inhibited, and the synthesis of cell receptors is increased. Serum cholesterol level controls the formation of cholesterol in the liver by regulating enzymes that synthesize cholesterol. 3. When serum cholesterol concentration is high, the synthesis of cholesterol in the liver is inhibited, and the synthesis of cell receptors is decreased. Serum cholesterol level controls the formation of cholesterol in the liver by regulating proteins that synthesize cholesterol. 4. When serum cholesterol concentration is high, the synthesis of cholesterol in the liver is inhibited, and the synthesis of cell receptors is decreased. Serum cholesterol level controls the formation of cholesterol in the liver by regulating enzymes that synthesize cholesterol. ### Explanation of Key Concepts - **Serum Cholesterol Concentration**: The amount of cholesterol present in the bloodstream. - **Cholesterol Synthesis in the Liver**: The process by which the liver produces cholesterol. - **Synthesis of Cell Receptors**: The production of cellular receptors, such as LDL receptors, which are involved in the uptake of cholesterol. ### Detailed Analysis #### Option Analysis: **Option 1:** Suggests that low serum cholesterol concentration inhibits cholesterol synthesis in the liver and increases receptor synthesis, with regulation through cholesterol-synthesizing proteins. **Option 2:** Suggests that high serum cholesterol concentration inhibits cholesterol synthesis in the liver and increases receptor synthesis, regulated by cholesterol-synthesizing enzymes. **Option 3:** Suggests that high serum cholesterol concentration inhibits cholesterol synthesis in the liver and decreases receptor synthesis, regulated by cholesterol-synthesizing proteins. **Option 4:** Suggests that high serum cholesterol concentration inhibits cholesterol synthesis in the liver and decreases receptor synthesis, regulated by cholesterol-synthesizing enzymes. #### Correct Answer: The correct answer is **Option 4:** - When serum cholesterol concentration is high, the synthesis of cholesterol in the liver is inhibited, and the synthesis of cell receptors is decreased. Serum cholesterol level controls the formation of cholesterol in the liver by
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