How does p53 induce apoptosis? How does the cell determine what "too much" damage is? Meaning, how can it tell if the damage to the DNA is too severe to fix in order for the cell to move on to S phase? Thank you.

How does p53 induce apoptosis? How does the cell determine what "too much" damage is? Meaning, how can it tell if the damage to the DNA is too severe to fix in order for the cell to move on to S phase? Thank you.

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter9: Cell Communication

Section: Chapter Questions

Problem 16RQ: Apoptosis can occur in a cell when the cell is damaged no longer needed infected by a virus all of...

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Step 2: Understand how p53 induce apoptosis

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Step 3: Assessing how the cell decides what "too much" damage

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Step 4: Cells understand that harm to the DNA is too extreme to fix for the cell to move on to the S stage

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4) Describe in detail how p53 and MDM2 regulate cell division in a normal, healthy cell. You should describe 1) how these proteins cooperate to allow a cell to go through the cell cycle, 2) how they cooperate to stop the cell cycle, and 3) how they allow the cell cycle to continue again after having stopped it initially. You may use point form if you want.
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Apoptosis can occur in a cell when the cell is damaged no longer needed infected by a virus all of the above
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