HO phenol pka 10 NH₂amine H N amide 2 IZ H N_ amide 1 thioester S OH carboxylic acid pka 5

Chemistry
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Chapter1: Chemical Foundations
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Amoxycillin is often adminisstered as the sodium salt. It is more soluble form that results from the reaction:

Amoxycillin + NaOH --> Sodium-amoxycillin + H2O

What functional grouo omn amoxycillin allows it to act as an acid in the reaction?

 

The image displays a chemical structure with various functional groups labeled:

1. **Phenol Group**: Located on the left side of the molecule, denoted by a hydroxyl group (-OH) attached to an aromatic ring. It is labeled with a pKa of approximately 10.

2. **Amine Group**: Indicated by the -NH2 group, located central in the structure and labeled as "amine."

3. **Amide Groups**: Two amide linkages are present:
   - **Amide 2**: Positioned next to the amine group.
   - **Amide 1**: Part of a larger heterocyclic ring structure.

4. **Thioester Group**: Identified by a sulfur atom (S) bonded to a carbonyl group (C=O), situated in the ring structure.

5. **Carboxylic Acid Group**: Found on the right side, denoted by the -COOH group, with a pKa of approximately 5.

This diagram effectively illustrates the molecular arrangement and provides insight into the acidity of different functional groups, as indicated by their respective pKa values.
Transcribed Image Text:The image displays a chemical structure with various functional groups labeled: 1. **Phenol Group**: Located on the left side of the molecule, denoted by a hydroxyl group (-OH) attached to an aromatic ring. It is labeled with a pKa of approximately 10. 2. **Amine Group**: Indicated by the -NH2 group, located central in the structure and labeled as "amine." 3. **Amide Groups**: Two amide linkages are present: - **Amide 2**: Positioned next to the amine group. - **Amide 1**: Part of a larger heterocyclic ring structure. 4. **Thioester Group**: Identified by a sulfur atom (S) bonded to a carbonyl group (C=O), situated in the ring structure. 5. **Carboxylic Acid Group**: Found on the right side, denoted by the -COOH group, with a pKa of approximately 5. This diagram effectively illustrates the molecular arrangement and provides insight into the acidity of different functional groups, as indicated by their respective pKa values.
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